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51 comments in c/science@lemmy.world view that post
[–] 108 points 10 months ago (10 children)

Holy shit. Directly treating the cause of cartilage loss with pill-form treatment in human trials right now. The shit we've been doing with medical science recently is fucking wild.

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  • [–] 17 points 10 months ago (8 children)

    Would've been useful before I had my foot cut off. 🤷‍♂️

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  • [–] 22 points 10 months ago (6 children)

    In 20 years you'll get a pill from the pharmacy to grow a new one 😋

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  • [–] 7 points 10 months ago (5 children)
  • [–] 13 points 10 months ago (3 children)

    TONIGHT ON DEAL OR NO DEAL:

    you can get this new leg but it will cost you a kidney

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  • [–] 55 points 10 months ago (17 children)

    As a 50+ year old mechanic, this can’t come soon enough.

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  • [–] 20 points 10 months ago (1 child)

    Wow yes. So many older and retired workers from the skilled trades could benefit from this.

    It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.

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  • [–] 10 points 10 months ago (6 children)

    Spoiler alert: you can't afford it.

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  • [–] 7 points 10 months ago (4 children)

    also cancer :)

    Any of the "regrows damage" side of thing scares the fuck out of me. I mean I want it to come and ASAP, but I also don't want to play chicken with C

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  • [–] -1 points 10 months ago (3 children)

    Cancer is largely based on your genetics, except for extreme causes like asbestos or smoking. It’s worth the risk.

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  • [–] 2 points 10 months ago (2 children)

    Not in this case.

    "Stem cells survive much longer than ordinary cells, increasing the chance that they might accumulate genetic mutations. It might take only a few mutations for one cell to lose control over its self-renewal and growth and become the source of cancer."

    https://www.hsci.harvard.edu/stem-cells-and-cancer

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  • [–] [S] 2 points 10 months ago (1 child)

    The news article, as well as the published work, state that:

    Cartilage regeneration appears to occur through gene expression changes in pre-existing chondrocytes, rather than stem or progenitor cell proliferation.

    Long-term side effects will need to researched of course and there might still be stem cells involved in the process, however that doesn't seem to be the case according to what we know as of now.

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  • [–] 13 points 10 months ago (6 children)

    Perfect for making you work the remainder of your life. No more arthritis? Great, now work until death to pay for it.

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  • [–] 15 points 10 months ago (1 child)

    So…there’s a chance I can back into martial arts? Bring it.

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  • [–] 32 points 10 months ago (1 child)

    The rich are going to live well

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  • [–] 21 points 10 months ago (3 children)

    Bet soon I can buy this from a roided up guy in the locker rooms of my local gym. Middle aged power lifters would love to pop these pills.

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  • [–] [S] 1 point 10 months ago (1 child)

    Most definitely. I'm almost in that demographic myself and several of the slightly older, nerdy lifters at my gym talk about BPC-157 as something they would consider using.

    If this gets proven to work in vivo in humans I'm certain we'll see the same no matter side effects.

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  • [–] 28 points 10 months ago
    [–] 16 points 10 months ago (5 children)

    Between this and growing new teeth, things are looking a lot more cyberpunk than before.

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  • [–] 8 points 10 months ago (3 children)
  • [–] 7 points 10 months ago (1 child)

    Damn mice's at this point they will reach immortality first. Then again thankful for that lol.

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  • [–] 5 points 10 months ago

    I wonder if you'd have to stay off of those joints for months to allow the regrowth to occur properly.

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  • [–] 3 points 10 months ago* (2 children)

    The question is "Does 15-PGDH do something beneficial and would suppressing it have serious side effects?"

    I found this:

    15-HPGD has an unappreciated role in the maintenance of pregnancy. In mice, 15-HPDG has been shown to have essential roles in prevention of early termination of pregnancy and maternal morbidity. In 15-HPGD knockout mice, early pregnancy termination was detected.

    So any 15-HPGD treatment would have to be done with careful consideration of woman of reproductive age.

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  • [–] 7 points 10 months ago

    What the fuck? All we ever needed was a pill? Is everybody stupid?

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  • 13 comments in c/interestingshare@lemmy.zip view that post
    [–] 12 points 10 months ago (11 children)

    These articles are always interesting but how do I get the treatment?

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  • [–] 21 points 10 months ago (2 children)

    Well, this shows promising results in phase 1.

    https://miamiclinicalresearch.com/how-long-do-clinical-trials-last-understanding-the-timeline/

    Most likely 5 years if nothing goes wrong.

    The timeline is going to be wildly different depending on the side effects, and how long people are expected to have to take the drug.

    It's exciting news. Odds are we won't see anything else about it soon, and it's likely they'll need to adjust something to make it work correctly, but this is the nature of research. Especially when it comes to medicine.

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  • [–] 10 points 10 months ago (1 child)

    That's great, thanks. A reasonable time line too, might be soon enough to save my knee.

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  • [–] 4 points 10 months ago

    Similar hope here. Exercise has kept the surgery at bay, 5 years in now (almost 6) since getting it diagnosed, and per the doctors ive got another 10 to go if I keep it up.

    So its possible for me too and I'm hopeful it works out.

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  • [–] 6 points 10 months ago (7 children)

    There been stuck in research land for years on end and some are just now in human testing. WHO classifies aging as a disease so would be considered a world wide treatment, however the question is how much is it and how much are your willing to pay?

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  • [–] 3 points 10 months ago (6 children)

    How much are you able to pay is the question.

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  • [–] 4 points 10 months ago (5 children)

    Ahh now we’re asking the right questions! Lol. We’ll try it as long as side effects aren’t terrible.

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  • [–] 4 points 10 months ago (4 children)

    I'm saying the potential cost in capitalist countries will make these treatments a luxury that the bull of the populace can't momentarily afford.

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  • [–] 2 points 10 months ago (3 children)

    This is true, hopefully it’s released when medicine and medical practices are better controlled.

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  • [–] 2 points 10 months ago (2 children)

    A pox on autocorrect lol. I'm glad you were able to grasp my approximate meaning.

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  • [–] 5 points 10 months ago

    May I have some?

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  • 8 comments in c/science@mander.xyz view that post
    [–] 22 points 10 months ago (1 child)

    Cool, can't wait to never hear about this again, or have access to it.

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  • [–] 6 points 10 months ago

    I get it, but we actually have made substantial progress over the last several decades in numerous medical fields. Look at the long term improvement in cancer outcomes. Every time a new treatment comes out, there are always people saying that only the rich will ever be able to afford it. And yet, in the long term, they're wrong every time.

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  • [–] 6 points 10 months ago (1 child)

    Researchers at Stanford Medicine report that blocking a protein linked to aging can restore cartilage that naturally wears away in the knees of older mice.

    In mice.

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  • [–] 2 points 10 months ago

    I’ll take two, please.

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  • [–] 1 point 10 months ago

    cells? cartilage doesn't have cells.

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  • [+] -10 points 10 months ago (1 child)

    That's more interesting that a lifting. But I could do the same by doing slow stretch and avoid alcohol. But if someday a doctor tells me to slow down on the cheese I'll remember that solution.

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  • [–] 9 points 10 months ago

    I work with hundreds of knee replacement patients a year. Stretching and teetotaling isn't necessarily going to prevent knee cartilage from diminishing. It's certainly healthy, and will benefit multiple aspects of your life and well-being, but you give it way too much credit in this instance.

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  • 7 comments in c/medicine@mander.xyz view that post
    [–] 18 points 10 months ago (3 children)

    pretty funny when Americans research healthcare because Americans aren't allowed to have healthcare

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  • [–] 7 points 10 months ago (1 child)

    What's funny is their system gets them money to fund top research but it's not going to serve most of their population, and about half of its voters are happy with it.

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  • [–] 6 points 10 months ago

    Published in November 2025, and the research was in mice and, "seems to suggest" that it could lead to regeneration of tissues in the knee. It is phenomenal, but far from being usable in an everyday medical setting yet...

    https://med.stanford.edu/news/all-news/2025/11/joint-cartilage-aging.html

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  • [–] 5 points 10 months ago (1 child)

    Another medical breakthrough... we'll be done with testing and ready for release in 2094.

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  • 6 comments in c/health@lemmy.world view that post
    [–] 15 points 10 months ago*

    It's a small molecule inhibitor of 15-PGDH. 15-PGDH degrades prostaglandin E2. Let's hope it works in humans too.
    Original article: https://doi.org/10.1126/science.adx6649

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  • [–] 13 points 10 months ago

    Holy cats! If that could be used for hands and finger joints.

    I recently jammed my right index finger and it's gone massively janky like insta-arthritic in the joint.. swollen, hot.. somewhat painful and VERY stiff. It is awful, all I can say is thank God, I'm left handed.

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  • [–] 6 points 10 months ago

    I need this for my right knee.

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  • [–] 2 points 10 months ago

    Gimme. Gimme gimme gimme.

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  • [–] 2 points 10 months ago

    I have hyperflexibility and all my collagen gets made wrong, I really hope this could help my godawful knees

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  • [–] 1 point 10 months ago

    Nice, my joints would like some. 😁

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  • 2 comments in c/science@beehaw.org view that post