I think the commenter in the picture was wooshed
post
Yeah, and you can't spread diesease while you're dead, can you Simon?
The amanitin toxin is heat stable, remaining toxic whether eaten raw or cooked. The mechanism of action of amatoxin is by inhibiting RNA polymerase, causing disruption of transcription of mRNA. As a result, hepatocytes cannot synthesize key protein coding genes, leading to the disintegration of nucleoli and pathologically centrilobular hepatic necrosis. This leads to the insidious onset of liver failure over 48 hours. Late onset (more than six hours after ingestion) of vomiting and watery diarrhea occur due to the second component in some of these mushrooms which are phallotoxin. Lepiota species lack phallotoxins so may not have the onset of vomiting and diarrhea until after 12 hours post-ingestion, or may just present with symptoms of liver failure at 24 hours post ingestion.
https://www.ncbi.nlm.nih.gov/books/NBK431052/
Wow ok 😬
Well, heat stable to a point, though not sure how tasty mushroom ashes would be
Mushrooms, as long as its done slowly, can be cooked for extremely long times at extremely high temperatures as the spongy matrix that makes up the majority of their tissue is far more stable to heat than other protiens. They tend to go deep into maillard style caramelization type reactions instead of carbonizing as ling as you're not incinerating them rapidly.
Edit: autocorrupt "Fixed" a word for me
Let's find out
I love reading about Death Cap mushrooms and their cousin, Destroying Angel. By the time symptoms appear, you've already got irreversible damage. Specifically for Destroying Angel, as of 2016 there was about a 50 percent survival rate, but by 2023 that number had jumped to 85-90%. There's no antidote. Mostly treatment is to hydrate the absolute fuck out of you so that you're peeing out the toxin and pumping you full of electrolytes. The key to survival is detecting it as soon as possible.
Were they the mushrooms that woman in Australia used to murder her ex-in-laws?
Allegedly.
That was the Death Caps. They're a bit more survivable than Destroying Angel, but I wouldn't want to eat either of them.
Certain temperatures can completely denature viruses like HIV and covid. Anything above 600 degrees should do the trick.
600 degrees Celsius or Fahrenheit?
I'm not sure it matters, bluntly.
First one, then the other.
Kelvin could do the trick too.
Rankine might be a little more iffy though...
I actually wonder how long it would take to notice if all your mRNA stopped working.
I don't think neuron action potentials rely directly on mRNA, so I think you'd be able to keep thinking for a bit, and probably moving your muscles too. The closest comparable thing is people that received massive radiation doses (can't make new RNA out of shredded DNA) and in those cases it takes a bit before you start melting.
I think it would be comparable to situation where all mRNA is suddenly unusable, ie protein synthesis can't run at all. This would be something like ricin or diphteria toxin poisoning, but instead of being limited to gastrointestinal lining it's spread all over. I'd guess hours to days before anything visible starts happening (symptoms only start to appear when deficit in new protein synthesis becomes noticeable; all protein already made continues to work for sone time)
Transcription + translation response time to stimulus is on the hour scale. So it wouldn't be instant. But if your other RNA buggered off then I have no idea. The non-mRNA.
Doesn't the death cap mushroom work by destroying your DNA? I would imagine the effect would be similar.
Don't destroying angel mushrooms basically stop your body from making proteins? That's roughly the same net effect as RNA stopping working so it should give you a pretty good approximation.
I mean, she's not wrong.
i thought that was the point
Wow they got our bodies addicted to mrna and now if we take them out we will die??!!!??
The person doesn't know how viruses work
First they fixate over protein metrics, and now they don't want the actual protein synthesis? Having high intake of amino acids was already not doing most of what they claimed, but now we're just gonna have our body not even use them? What a waste of resources. 0/10 (/s)
Waitaminute. Are you telling me there are stupid people on the internet talking about things they don't understand?
The internet is the worst thing we've ever done to ourselves. I mean, it was fine at first. But we didn't have enough cynicism to account for what corporations would do with it and that's, sadly, our own fault for being too naive.
We also underestimated the number of idiots in the population. Or their ability to find little niches in which to congregate.
I like us building alternatives on the internet. The fediverse makes me hopeful again.
The internet is still okay, just don't use any corporate social network and generally ignore everything made by corporations.
We had really high hopes and big dreams for the Internet when it was conceived.
We ended up with social networks that steal and sell you information without your knowledge, and without any compensation to you, and "AI" slop for chat bots, and forum posts and pictures and even video now....
This is not what the Internet was made for.
I don't know if it's true, but it feels like the Internet was better when it was limited to enthusiasts and people in higher education.
Letting every idiot post every word that comes to mind for the whole world to see was probably a mistake.
🌈 classism 🌈
This is a joke. Have you considered the possibility that you are the stupid person in this case?
I mean you clearly demonstrated how stupid you are, "let's nuke the internet".
When did I say anything remotely like that? Thanks for calling me stupid for making an observation.
top 66 comments