Yall are fuckin wierd lol. I absolutely love cannabis, both recreationally and medically. But if there's an additional choice to isolate the pain relief aspect without the psychoactive effects of THC, that would be amazing as well. It's not an either/or choice - there are absolutely use cases for both. Regardless, I'm pretty skeptical that terpenes are any more useful for pain control than essential oils are.
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What do you think happened to cocaine and heroine? Hell, alcohol some places.
What happened to them? I really don't know the history behind these hard drugs.
They started as medicines and were concentrated, distilled, and extracted to the point where the medicine it became was deadlier than the cure it provided.
Coca leaves are still consumed medicinally/recreationally in some parts of south america.
Poppy seeds have a whole history of being abused and weaponized through the silk road.
Marijuana has faced a similar story, though without the deaths. This hasn't stopped governments around the world from conflating the deaths caused by other things with the use of medicines that in no way cause death.
I have to point out that in medicine we use the derivatives from cocaine, novacaine, lidocaine, benzocaine etc as potent short/medium term anaesthetics. Drugs like these make dental extractions for example relatively painless today. Pure cocaine was used previously but was far more toxic to the liver and had a much higher incidence of allergic reaction than its modern derivatives.
I miss my MJ, but it fucks with my heart so it’s a no go for me. It was critical to my recovery after a head on collision and the after effects. Doc was prescribing dilaudid, and that shit is something like sythentic heroin and his nurse i calling like every week to find out why i never filled the rx.
Nooo thanks. I hope this proves to be viable.
Weed smells like pine trees because they both have the chemical in this "study".
https://www.webmd.com/diet/what-to-know-pine-needle-tea
It's way easier and basically free if you have any sort of access to a pine tree.
Which is why no one pays for studies about that method.
who told you weed smells like pine? am i the only one who thinks that's crazy?
If you haven't noticed, there's a shit kind of different weeds.
That is mainly due to varying terepens.
Some weed, smells like pine tree to various degrees.
Hey, that's cool! This seems promising for enabling people dealing with chronic pain to have more options for ways to control pain without needing to potentially compromise mental function when they need it. Now to scroll through the comment section to see everyone's completely reasonable and measured takes.
Hey welcome to the internet friend, I hope you enjoy your first day!
Pass.
Call me when they develop weed without pain relief that only gets you high as giraffe balls.
Huh...I've always heard "giraffe pussy." Lol I never thought about it the other way.
I hate the pain relief/numbing aspect of some strains, it makes me get comfortable in positions that don't make me feel bad til the nexy day and then I feel bad for a week
Maybe you and I can go splits. You can have my share of the stone if I can have the pain relief part.
Call me when they develop weed that gives all the pain and none of the relief!
Let's spice things up, russian roulette with weed instead of bullets.
so they have these gummy bears with a shitton of capsaican, like 9,000,000 scovilles or something. you're supposed to chew them for 5 minutes, and they say it's like getting maced in the mouth. maybe a 6/10 of pain or something, it's intense but it's over fast. also you can make it easier with milk, that'd probably drop it down to a 4/10 or something. But 5 minutes and it's over.
if you want a pain russian roulette, use those.
Ngl that just sounds like my normal weed for years. Originally took it for foot pain after work and it did nothing, but I was high as fuck and didn't care that much
that's kind of how it works though. The first time i took weed I was doing 12 hour shifts in kitchen work, and i noted how it didn't remove the pain, it just made me stop careing about it.
Definitely still couldn't walk properly because of pain, seems a bit pointless, but that's just me
Call me when they invent weed that makes me feel like I'm wearing grade 7 nipple clamps
without the high, double blind human trials will be relatively easy. looking forward to that.
- Original Article;
- Article is from March 18, 2025;
- I personally don't reccomend following sciencedaily as they seem to have bad practices like publishing old articles frequently.
And then it gets patented and costs $10,000 a dose.
Currently happening with kratom and psylocibin as well.
Yeah, the most legit meds come from a gas station.
I don't think you know what you're talking about. There are multiple patents pending on modified kratom alkaloids.
https://en.wikipedia.org/wiki/Deuterated_mitragynine?wprov=sfla1
I've read about others but that was the first one I came across in development.
Psilocin pro-drugs are another category with multiple patents pending, Mindset Pharma holding a few.
https://en.wikipedia.org/wiki/MSP-1014?wprov=sfla1
Here is another patented by Reunion Neuroscience.
But like, the buzz cures pain too. Or is no one else dealing with depression?
Can I get the high without the pain relief? I don't like risking overdose on too many marijuanas
They made it suck.
They already did this a long time ago, with Marinol, a course of which costed like 20k, while a 50 dollar baggie of weed would better do the job.
I’d use it, if it were legal and wouldn’t threaten my job. I have no interest in getting high.
My dad his disautonomia so he has to smoke weed in order to cope with the pain from his nervous system.
He'd rather not use pain killers aka morphine aka opiates for risk of getting addicted to those.
Hopefully this compound will help his pain tolerance without giving him the high
Because god forbid anyone ever feel a high that doesnt benefit corporate cartels.
Because you’re not allowed to feel good with any medical treatment.
No.
Or because plenty of people want medicine without unwanted side effects.
On one hand, it sounds like Puritanical bullshit, but on the other hand, I’d like the option.
Idk some people like going to work without pain.
For me cannabis is an incredibly strong depressant. I can feel suicidal for free with pain, thanks.
This is so stupid. Just more pointless research to make you look the wrong way. Like Cannabis is this miracle plant that could offer us things we didn't have access to before.
I love Cannabis, she has been one of my best friends for over 25 years but let's not kid ourselves. These terpenes aren't unique to Cannabis, you shouldn't be getting them from Cannabis, you should be getting them from your food.
Unfortunately the food you are sold is dead and empty. Not only are processed foods stripped of all you actually need to support a healthy body, the fruits and veggies you buy are mostly dead strains that are grown in dead soil. It's cheaper upfront, but then you have to pay for it in supplements, taxes and hospital bills.
Geraniol: Citronella, rose, lemongrass
Linalool: Lavender, mints, citrus, coriander, basil
Beta-caryophyllene: Black pepper, rosemary, cloves, hops
Alpha-humulene: Sage, hops, ginseng, ginger, mints
Terpenes are the key. Spice up your lives.
Slam it to the left if you're havin' a good time, shake it to the right If ya know that you feel fine
Devil weed, everyone involved should be killed and the research burned.
That's why they are finding out about this now and not 1950. Witch hunts are so great, everyone benefits (not).
Publically. Bonfire style. In the middle of city square.
Instructions unclear, now someone's hosting an execution-themed costume party downtown while blasting Childish Gambino Bonfire mashups
Not* sure how that's possible because the high is what relieves the pain for me. Not thinking about pain when I'm stoned off my ass.
I'm not sure how you can objectively say the high is what gives pain relief. The two are intrinsically linked for you, and you'd be unable to know if it's one or two chemical processes happening in your body at the same time. It's just impossible to know.
We'd just have to try it and find out, I guess.
Surely couldn't hurt, especially if it doesn't affect your tolerance for THC. Cause I really need to take a tolerance break, but I need pain relief and sleep more.
What about CBD-based sleep aid gummies?
Unfortunately I've been there, done that. I feel nothing from CBD whatsoever. No pain relief, no appetite, no sleep. Feels like eating a snack
Nope, I need my THC, so it'll be interesting to see how this discovery plays out. Maybe I can finally get the relief I need without worrying about needing t-breaks.
Yeah unfortunately I'm the same way. Have tried several CBD things and not one of them do anything for me unless I go max dose, and even then it's an incredibly mild effect. THC takes nearly nothing though, 15mg is enough for a very strong high. I have friends where the complete opposite is true and I would love to trade them.
I would love to trade them.
Having a low tolerance is great for your wallet!
Oh it absolutely is, and I've got a low tolerance for alcohol too, which is pretty nice. I just wish that if I had to choose which of THC and CBD I had a low tolerance for, it'd be CBD.
Damn you're so lucky; I have a naturally high tolerance to everything. Even if it's my first time trying a substance, I usually need double the recommended starter dose to even feel anything. It definitely hasn't been great on my wallet.
Damn that's rough and sounds expensive!
It's funny, the first few times I smoked a joint with a friend, it barely did anything at all to me. Never had any more for many years, and the next time I was completely couch locked and was hallucinating while watching TV. Either my tolerance changed drastically or my friend's weed was weak as hell.
Reduces pain in mouse models?
It's a nice way of saying:
We gave mice _____ to see if we could cure them of ____!
https://pmc.ncbi.nlm.nih.gov/articles/PMC8621025/
Explains it more in depth:
Understanding and treating human diseases requires thorough knowledge of disease-causing molecular and pathophysiological mechanisms. Despite the recent advances in induced pluripotent stem cell techniques, many of these aspects remain challenging to study, especially under physiological conditions in patient-derived material [1,2]. In order to be reliable and valuable, the disease model should recapitulate if not the entire human disease phenotype, then at least the key features of each specific disease under study [3]. For precision medicine, a good understanding of the genetic bases of variation in phenotypes and their interaction with the environment in health and disease are required [4,5]. Thus, animal models, and especially genetically modified (GM) mice, offer great potential to serve as precious preclinical models that facilitate basic understanding of disease pathomechanisms and provide clues for the development of treatment options and novel strategies to follow a treatment’s response.
Well where's there fun in that!?
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