top 98 comments

sorted by: hot top controversial new old
[–] 58 points 4 months ago (7 children)

Yall are fuckin wierd lol. I absolutely love cannabis, both recreationally and medically. But if there's an additional choice to isolate the pain relief aspect without the psychoactive effects of THC, that would be amazing as well. It's not an either/or choice - there are absolutely use cases for both. Regardless, I'm pretty skeptical that terpenes are any more useful for pain control than essential oils are.

  • source
  • hideshow 7 child comments
  • [–] 0 points 4 months ago (3 children)

    If I'm not wrong, essential oils are rich in terpenes and maybe that's what makes them useful as a pain treatment.

  • source
  • parent
  • hideshow 3 child comments
  • [–] 15 points 4 months ago (2 children)

    Essential oils are not useful as pain treatment.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 1 point 4 months ago (1 child)

    I have friends that use them and disagree.

  • source
  • parent
  • hideshow 1 child comment
  • [–] 4 points 4 months ago*

    You have friends that have made a therapeutic ritual out of using essential oils which helps them only because the placebo effect can be very powerful for pain. Literally anything could stand in for the essential oils. Swap their oil vials out with convincing fakes and they'll never know the difference because it's the ritual of smelling and/or applying the oils that's helping them, not any real physical mechanism of the compounds in the oils interacting with their biology.

  • source
  • parent
  • [+] 25 points 4 months ago (4 children)
  • [–] 9 points 4 months ago (3 children)

    What do you think happened to cocaine and heroine? Hell, alcohol some places.

  • source
  • parent
  • hideshow 3 child comments
  • [–] 3 points 4 months ago (2 children)

    What happened to them? I really don't know the history behind these hard drugs.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 9 points 4 months ago (1 child)

    They started as medicines and were concentrated, distilled, and extracted to the point where the medicine it became was deadlier than the cure it provided.

    Coca leaves are still consumed medicinally/recreationally in some parts of south america.

    Poppy seeds have a whole history of being abused and weaponized through the silk road.

    Marijuana has faced a similar story, though without the deaths. This hasn't stopped governments around the world from conflating the deaths caused by other things with the use of medicines that in no way cause death.

  • source
  • parent
  • hideshow 1 child comment
  • [–] 3 points 4 months ago

    I have to point out that in medicine we use the derivatives from cocaine, novacaine, lidocaine, benzocaine etc as potent short/medium term anaesthetics. Drugs like these make dental extractions for example relatively painless today. Pure cocaine was used previously but was far more toxic to the liver and had a much higher incidence of allergic reaction than its modern derivatives.

  • source
  • parent
  • [–] 23 points 4 months ago (7 children)

    I miss my MJ, but it fucks with my heart so it’s a no go for me. It was critical to my recovery after a head on collision and the after effects. Doc was prescribing dilaudid, and that shit is something like sythentic heroin and his nurse i calling like every week to find out why i never filled the rx.

    Nooo thanks. I hope this proves to be viable.

  • source
  • hideshow 7 child comments
  • [–] 7 points 4 months ago (6 children)

    Weed smells like pine trees because they both have the chemical in this "study".

    https://www.webmd.com/diet/what-to-know-pine-needle-tea

    It's way easier and basically free if you have any sort of access to a pine tree.

    Which is why no one pays for studies about that method.

  • source
  • parent
  • hideshow 6 child comments
  • [–] 12 points 4 months ago (5 children)

    who told you weed smells like pine? am i the only one who thinks that's crazy?

  • source
  • parent
  • hideshow 5 child comments
  • [–] 11 points 4 months ago (3 children)

    https://www.leafly.com/news/cannabis-101/what-is-pinene-and-what-are-the-benefits-of-this-cannabis-terpene

    If you haven't noticed, there's a shit kind of different weeds.

    That is mainly due to varying terepens.

    Some weed, smells like pine tree to various degrees.

  • source
  • parent
  • hideshow 3 child comments
  • [–] 43 points 4 months ago (2 children)

    Hey, that's cool! This seems promising for enabling people dealing with chronic pain to have more options for ways to control pain without needing to potentially compromise mental function when they need it. Now to scroll through the comment section to see everyone's completely reasonable and measured takes.

  • source
  • hideshow 2 child comments
  • [–] 118 points 4 months ago* (13 children)

    Pass.

    Call me when they develop weed without pain relief that only gets you high as giraffe balls.

  • source
  • hideshow 13 child comments
  • [–] 6 points 4 months ago*

    I hate the pain relief/numbing aspect of some strains, it makes me get comfortable in positions that don't make me feel bad til the nexy day and then I feel bad for a week

  • source
  • parent
  • [–] 3 points 4 months ago (1 child)

    Call me when they develop weed that gives all the pain and none of the relief!

    Let's spice things up, russian roulette with weed instead of bullets.

  • source
  • parent
  • hideshow 1 child comment
  • [–] 3 points 4 months ago

    so they have these gummy bears with a shitton of capsaican, like 9,000,000 scovilles or something. you're supposed to chew them for 5 minutes, and they say it's like getting maced in the mouth. maybe a 6/10 of pain or something, it's intense but it's over fast. also you can make it easier with milk, that'd probably drop it down to a 4/10 or something. But 5 minutes and it's over.

    if you want a pain russian roulette, use those.

  • source
  • parent
  • [–] 2 points 4 months ago (4 children)

    Ngl that just sounds like my normal weed for years. Originally took it for foot pain after work and it did nothing, but I was high as fuck and didn't care that much

  • source
  • parent
  • hideshow 4 child comments
  • [–] 1 point 4 months ago (3 children)

    that's kind of how it works though. The first time i took weed I was doing 12 hour shifts in kitchen work, and i noted how it didn't remove the pain, it just made me stop careing about it.

  • source
  • parent
  • hideshow 3 child comments
  • [–] 2 points 4 months ago (1 child)

    Definitely still couldn't walk properly because of pain, seems a bit pointless, but that's just me

  • source
  • parent
  • hideshow 1 child comment
  • [–] 47 points 4 months ago

    Sounds shit. Gimme both tx

  • source
  • [–] 11 points 4 months ago*

    without the high, double blind human trials will be relatively easy. looking forward to that.

  • source
  • [–] 8 points 4 months ago*
    1. Original Article;
    2. Article is from March 18, 2025;
    3. I personally don't reccomend following sciencedaily as they seem to have bad practices like publishing old articles frequently.
  • source
  • [–] 21 points 4 months ago (3 children)

    And then it gets patented and costs $10,000 a dose.

  • source
  • hideshow 3 child comments
  • [–] 9 points 4 months ago (2 children)

    Currently happening with kratom and psylocibin as well.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 1 point 4 months ago (1 child)

    Yeah, the most legit meds come from a gas station.

  • source
  • parent
  • hideshow 1 child comment
  • [–] 4 points 4 months ago

    I don't think you know what you're talking about. There are multiple patents pending on modified kratom alkaloids.

    https://en.wikipedia.org/wiki/Deuterated_mitragynine?wprov=sfla1

    I've read about others but that was the first one I came across in development.

    Psilocin pro-drugs are another category with multiple patents pending, Mindset Pharma holding a few.

    https://en.wikipedia.org/wiki/MSP-1014?wprov=sfla1

    Here is another patented by Reunion Neuroscience.

    https://en.wikipedia.org/wiki/RE-109?wprov=sfla1

  • source
  • parent
  • [–] 14 points 4 months ago (1 child)

    But like, the buzz cures pain too. Or is no one else dealing with depression?

  • source
  • hideshow 1 child comment
  • [–] 7 points 4 months ago (1 child)

    Can I get the high without the pain relief? I don't like risking overdose on too many marijuanas

  • source
  • hideshow 1 child comment
  • [–] 13 points 4 months ago (2 children)
  • [–] 18 points 4 months ago

    Has science gone too far?

  • source
  • [–] 22 points 4 months ago

    I’d use it, if it were legal and wouldn’t threaten my job. I have no interest in getting high.

  • source
  • [–] 12 points 4 months ago

    My dad his disautonomia so he has to smoke weed in order to cope with the pain from his nervous system.

    He'd rather not use pain killers aka morphine aka opiates for risk of getting addicted to those.

    Hopefully this compound will help his pain tolerance without giving him the high

  • source
  • [–] 5 points 4 months ago

    Damn science! Ruining everything for everybody! /s

  • source
  • [–] 19 points 4 months ago (2 children)

    Because god forbid anyone ever feel a high that doesnt benefit corporate cartels.

  • source
  • hideshow 2 child comments
  • [–] 48 points 4 months ago (5 children)

    Because you’re not allowed to feel good with any medical treatment.

    No.

  • source
  • hideshow 5 child comments
  • [–] 8 points 4 months ago

    Is it a noose made of hemp

  • source
  • [–] 13 points 4 months ago
    [–] 16 points 4 months ago* (3 children)

    This is so stupid. Just more pointless research to make you look the wrong way. Like Cannabis is this miracle plant that could offer us things we didn't have access to before.

    I love Cannabis, she has been one of my best friends for over 25 years but let's not kid ourselves. These terpenes aren't unique to Cannabis, you shouldn't be getting them from Cannabis, you should be getting them from your food.

    Unfortunately the food you are sold is dead and empty. Not only are processed foods stripped of all you actually need to support a healthy body, the fruits and veggies you buy are mostly dead strains that are grown in dead soil. It's cheaper upfront, but then you have to pay for it in supplements, taxes and hospital bills.

    Geraniol: Citronella, rose, lemongrass

    Linalool: Lavender, mints, citrus, coriander, basil

    Beta-caryophyllene: Black pepper, rosemary, cloves, hops

    Alpha-humulene: Sage, hops, ginseng, ginger, mints

    Terpenes are the key. Spice up your lives.

  • source
  • hideshow 3 child comments
  • [–] 8 points 4 months ago (2 children)

    Slam it to the left if you're havin' a good time, shake it to the right If ya know that you feel fine

  • source
  • parent
  • hideshow 2 child comments
  • [–] 11 points 4 months ago

    Booooringg.

  • source
  • [–] 3 points 4 months ago

    I thought we knew how to do that for decades already

  • source
  • [–] 12 points 4 months ago (6 children)

    Devil weed, everyone involved should be killed and the research burned.

  • source
  • hideshow 6 child comments
  • [–] 6 points 4 months ago (3 children)

    Publically. Bonfire style. In the middle of city square.

  • source
  • parent
  • hideshow 3 child comments
  • [–] 7 points 4 months ago (2 children)

    Instructions unclear, now someone's hosting an execution-themed costume party downtown while blasting Childish Gambino Bonfire mashups

  • source
  • parent
  • hideshow 2 child comments
  • [–] 4 points 4 months ago* (last edited 4 months ago) (10 children)

    Not* sure how that's possible because the high is what relieves the pain for me. Not thinking about pain when I'm stoned off my ass.

  • source
  • hideshow 10 child comments
  • [–] 1 point 4 months ago

    I'm not sure how you can objectively say the high is what gives pain relief. The two are intrinsically linked for you, and you'd be unable to know if it's one or two chemical processes happening in your body at the same time. It's just impossible to know.

  • source
  • parent
  • [–] 1 point 4 months ago (8 children)

    We'd just have to try it and find out, I guess.

  • source
  • parent
  • hideshow 8 child comments
  • [–] 1 point 4 months ago (7 children)

    Surely couldn't hurt, especially if it doesn't affect your tolerance for THC. Cause I really need to take a tolerance break, but I need pain relief and sleep more.

  • source
  • parent
  • hideshow 7 child comments
  • [–] 1 point 4 months ago (6 children)

    What about CBD-based sleep aid gummies?

  • source
  • parent
  • hideshow 6 child comments
  • [–] 2 points 4 months ago* (5 children)

    Unfortunately I've been there, done that. I feel nothing from CBD whatsoever. No pain relief, no appetite, no sleep. Feels like eating a snack

    Nope, I need my THC, so it'll be interesting to see how this discovery plays out. Maybe I can finally get the relief I need without worrying about needing t-breaks.

  • source
  • parent
  • hideshow 5 child comments
  • [–] 2 points 4 months ago (4 children)

    Yeah unfortunately I'm the same way. Have tried several CBD things and not one of them do anything for me unless I go max dose, and even then it's an incredibly mild effect. THC takes nearly nothing though, 15mg is enough for a very strong high. I have friends where the complete opposite is true and I would love to trade them.

  • source
  • parent
  • hideshow 4 child comments
  • [–] 2 points 4 months ago (3 children)

    I would love to trade them.

    Having a low tolerance is great for your wallet!

  • source
  • parent
  • hideshow 3 child comments
  • [–] 3 points 4 months ago (2 children)

    Oh it absolutely is, and I've got a low tolerance for alcohol too, which is pretty nice. I just wish that if I had to choose which of THC and CBD I had a low tolerance for, it'd be CBD.

  • source
  • parent
  • hideshow 2 child comments
  • [–] 2 points 4 months ago* (1 child)

    Damn you're so lucky; I have a naturally high tolerance to everything. Even if it's my first time trying a substance, I usually need double the recommended starter dose to even feel anything. It definitely hasn't been great on my wallet.

  • source
  • parent
  • hideshow 1 child comment
  • [–] 1 point 4 months ago

    Damn that's rough and sounds expensive!

    It's funny, the first few times I smoked a joint with a friend, it barely did anything at all to me. Never had any more for many years, and the next time I was completely couch locked and was hallucinating while watching TV. Either my tolerance changed drastically or my friend's weed was weak as hell.

  • source
  • parent
  • [–] 2 points 4 months ago

    Illegal... and highly dangerous for reasons in 3, 2, 1

  • source
  • [–] 2 points 4 months ago (1 child)

    Reduces pain in mouse models?

  • source
  • hideshow 1 child comment
  • [–] 3 points 4 months ago

    It's a nice way of saying:

    We gave mice _____ to see if we could cure them of ____!

    https://pmc.ncbi.nlm.nih.gov/articles/PMC8621025/

    Explains it more in depth:

    Understanding and treating human diseases requires thorough knowledge of disease-causing molecular and pathophysiological mechanisms. Despite the recent advances in induced pluripotent stem cell techniques, many of these aspects remain challenging to study, especially under physiological conditions in patient-derived material [1,2]. In order to be reliable and valuable, the disease model should recapitulate if not the entire human disease phenotype, then at least the key features of each specific disease under study [3]. For precision medicine, a good understanding of the genetic bases of variation in phenotypes and their interaction with the environment in health and disease are required [4,5]. Thus, animal models, and especially genetically modified (GM) mice, offer great potential to serve as precious preclinical models that facilitate basic understanding of disease pathomechanisms and provide clues for the development of treatment options and novel strategies to follow a treatment’s response.

  • source
  • parent
  • [–] 2 points 4 months ago

    Could be a motive to disallow the sale of cannabis seeds.

  • source
  • [–] 3 points 4 months ago

    Lol. Where's the fun then haha? /s

  • source
  • [–] 3 points 4 months ago (1 child)

    Well where's there fun in that!?

  • source
  • hideshow 1 child comment
  • load more comments
    view more: next ›