Ummm, so it's been about 10 days now since I stopped taking cypro. I'm effectively on monotherapy now, only valerate injections.

I take 5mg of EV every 4 days. I'm a bit worried, because last time, my trough was only 110pg/ml at this dosage...and now I'm not taking cypro. So I'm worried my T will rise.

What also fuels my worries is what's been happening to my body. I don't smell worse or any different really, my skin seems the same, I'm not any oiler...but my libido is definitely changing. And...I'm not sure I like it.

I just have a higher libido in general (you've seen my 196 posts lol). I have dirty thoughts waaaay more often and these thoughts also cause reactions in me...meaning erections (ew, hate it).

They're nothing like they were pre-HRT, but still...I'm not sure it's a good thing. There's also something else...
I noticed that there's more...leakage...than there ever was before. Just from arousal, not climax (I haven't had one in a loooong time). There's like literally a string of whatever the fuck this clear fluid is...

There was never any leakage before and I certainly didn't have this much functionality...and I'm not sure I like it tbh. If you told me it was normal and that mono was working, I'd be like "cool". But since I'm only getting a blood test in a couple of weeks, I'm worried...I'm worried my T is rising and I'm ruining my transition. I'm afraid I'll lose a whole month of HRT because of mono...

Basically...I desperately need some words of comfort right now please. I'm actually freaking out, cause HRT is like one of the most important things to me. And I really want everything to go well...
Please girlies, HALP 😭

all 35 comments

sorted by: hot top controversial new old
[–] 11 points 3 days ago (11 children)

Estrogen Monotherapy will suppress T once the dosage is right. The fluid being clear is an indication of low T I believe.

  • source
  • hideshow 11 child comments
  • [–] [S] 5 points 3 days ago (10 children)

    The problem is, it's either 5mg every 3 days, which makes my trough go up to 800+pg/ml or 5mg every 4 days, which resulted in 110pg/ml last time. And I can't easily change the dosage without inconsistency, cause it's a single-use ampule.

    This official valerate kinda sucks 😭

  • source
  • parent
  • hideshow 10 child comments
  • [–] 4 points 3 days ago (5 children)

    what's wrong with 800pg/mL? my trough levels are like 1000 and i know plenty of people who are significantly higher than that and have been for years. unless you have a family history of blood clotting, it should be just fine

  • source
  • parent
  • hideshow 5 child comments
  • [–] [S] 4 points 3 days ago* (4 children)

    Nonono, you most certainly mean 1000pmol/L which is the "European unit" and 1000pmol/L is about 272pg/ml. That's not high at all, that's what I'd call the ideal trough, but 800pg/ml...is astronomically high E.

    Edit: For context, 1000pg/ml is about 3670pmol/L which is actually almost what I had on my last blood test. So...yeah, pretty high πŸ˜…

  • source
  • parent
  • hideshow 4 child comments
  • [–] 2 points 2 days ago (3 children)

    The problem is, it’s either 5mg every 3 days, which makes my trough go up to 800+pg/ml or 5mg every 4 days

    You're on injections. Why the hell is your dose fixed at 5 mg? Why is the only thing you can change the frequency? Try injecting 4 mg every 3 days.

  • source
  • parent
  • hideshow 3 child comments
  • [–] [S] 1 point 1 day ago (2 children)

    It's a single-use ampule, although...now I realize I don't have to use all of it at once. I'm pretty stupid, y'know? :P

  • source
  • parent
  • hideshow 2 child comments
  • [–] 2 points 1 day ago* (last edited 1 day ago) (1 child)

    Ah that makes sense. Also, another thing you can do. You can actually split an ampoule into multiple injections. For example, you could do two 2.5 mg injections every 2-3 days. When you open an ampoule, use it to fill two syringes. Use one immediately. Recap the other, keep it in clean dark place, and use it a few days later.

    You wouldn't want to open an ampoule, use half of it, leave it open to the air, and redraw from the ampoule a few days later. But if you immediately draw the ampoule into two different syringes, it will only be exposed to the air for a brief moment. Letting the solution sit in a sealed syringe for a few days won't do any harm. I wouldn't store something this way for weeks, months, or years, but a few days won't hurt.

    Admittedly this does go against standard medical advice and best practice. Generally clinical guidelines are to not do this. But IMO it really depends how precious your HRT supply is. If you're struggling to access it, struggling to afford it, and every last drop needs to be used most effectively? Then I would argue using it efficiently overwhelms perfect adherence to clinical guidelines. If you can afford to throw a third of your HRT solution away, then just use what you need from a vial and throw it out. But if you can't afford to do that, storing some of the vial in a syringe for a few days works in a pinch.

  • source
  • parent
  • hideshow 1 child comment
  • [–] [S] 1 point 1 day ago

    I'm not struggling to afford my HRT supplies. Yeah, it's more expensive than DIY, which is funny, but I'm not struggling to get it.

    That makes sense and I could do that. My endo would probably be fine with it and my levels would be better...but idk, I'd honestly rather not. I'm trying 5mg every 4 days now, along with 25mg of cypro every three days, which should give me sane-ish E levels while keeping my T low.

    Anyway, thanks for the comment! πŸ’œ
    It's just...I'm pretty stubborn and I really don't wanna mess around with halving my ampule doses :P
    Sorry! Thanks 🩷

  • source
  • parent
  • load more comments (-1 replies)
  • [–] 9 points 3 days ago* (1 child)

    Yeah that's perfectly normal, I've been on mono for w while and this is normal for me, as long as the pre is clear and not white, it means T is suppressed :)

  • source
  • hideshow 1 child comment
  • [–] 8 points 3 days ago (3 children)

    Totally normal sis. My libido fluctuates a lot with my hormone injection cycle. The clear fluid is a change but you get used to it. Your cowper glands secrete pre-seminal fluid in a similar way to Bartholin's glands do for people with vulvas.

    Ive never really confirmed it but my understanding was that Bartholin's glands produce more fluid than Cowper glands do to fully lubricate the vagina. So now that youre on E your body increases the production of the fluid from your cowper glands.

    You can more or less think of it as getting wet.

  • source
  • hideshow 3 child comments
  • [–] 2 points 2 days ago (1 child)

    You can more or less think of it as getting wet.

    I mean, maybe TMI, but that's literally how it is in my case. I'm post-op. I had SRS with Chettawut, and the way his site describes it:

    "Yes. Self-lubrication is possible because remnant para-urethral glands and an intact Cowper’s gland are preserved and incorporated into the reconstruction."

    And I have to say, in my case it worked. My husband and I are able to have PIV without any needing any exogenous lubrication. It just requires a good bit of foreplay. But yeah...beyond a shadow of a doubt, I definitely "get wet" so to speak.

  • source
  • parent
  • hideshow 1 child comment
  • [–] 5 points 3 days ago (1 child)

    I'm no expert, can only repeat what I was told... that E do not work without getting rid of T. As having T nullify E, that's why transmasc do not need any blockers of their natural E, they just get T, and the T override E, job done. Maybe with enough amount of E, natural amount of T wouldn't do the thing? But that big amount of E wouldn't be risky on other aspects? My source on that is only rumoured. Personally, Quick research points that mono E have weaker/partial effects only, if that's what You want, then maybe? I wouldn't risk it without asking the doc first.

    For now, lets hug, much. <HUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUG>

  • source
  • hideshow 1 child comment
  • [–] 4 points 3 days ago (1 child)

    To be fair, I have lower T than most cis women.

    And there is no panties of mine left without leakage 🀭 Even if I'm probably less horny than you (but any sexual stimulation I feel it sooo much)

  • source
  • hideshow 1 child comment
  • [–] 4 points 3 days ago (4 children)

    I kinda understood that the leakage part was, in fact, expected throughout the transition ?

    Sorry, HRT I'm not still there yet … but I think it's okay girl and you should be fine.

    Please dear people roaming here, catch me if I am wrong here, I just try to comfort my sister T_T

  • source
  • hideshow 4 child comments
  • [–] [S] 3 points 3 days ago (3 children)

    I thought leakage as in incontinence is expected during HRT, which yeah, happens too ;-;

    But this is different. This is purely from arousal and it's like...it's the closest to getting wet I've ever gotten. Which is cool, but I'm worried it's my T 😭

    I'm so worried it's my T rising omfg 😭😭😭

  • source
  • parent
  • hideshow 3 child comments
  • [–] 4 points 3 days ago (2 children)

    Oh I see, it's going to be okay love, right ?

    Whatever happens, you will see your results and your specialist will give guidance, right ? However people here will find a way to help you. Nothing's lost πŸ«‚

  • source
  • parent
  • hideshow 2 child comments
  • [–] [S] 4 points 3 days ago (1 child)

    It'll be okay, I'll be fine...I'm trying to breathe. Phew, I'm actually really stressed from this! My bf is starting to get pissed cause I worry about it so much, but it's super important to me 😭

    Thank you sis πŸ«‚
    Nothing is lost. I'll be fine in the end. Thank you ❀️

  • source
  • parent
  • hideshow 1 child comment
  • [–] 4 points 3 days ago

    From my experience: EV monotherapy suppressed T just fine, for years. My libido was pretty much always higher on injection day, and my levels were never in danger of β€œruining” things.

    I did progesterone for probably 5 years, the last 3.5 were oral because I was sick of administering it after a while. Stopping it didn’t really seem to undo much by then.

  • source
  • [–] 3 points 3 days ago (2 children)

    I take 4mg of EV once per week, and at 3.5 days post injection I just tested 296 pg/mL. My T is 26 ng/dL.

    I've been on EV monotherapy (I do also take progesterone) for about 3 years, and I've been EV injections for ~6 years, with pills for about a year before that. I was on spironolactone for my T blocker up until I switched to monotherapy.

    I get similar leakage to what you've described, though I was getting that while on my tblocker as well. The only thing that really changed for me after switching to monotherapy was no more side effects from the spiro (mainly, I'm not always thirsty while also needing to pee all the time).

  • source
  • hideshow 2 child comments
  • [–] [S] 2 points 3 days ago (1 child)

    I'm glad it's working for you! Happy for you 🩷

    I have a question tho. Why do you test midweek? The most important measurement is the trough, which is right before the next injection. You want to be measuring the lowest E levels you have, is that not correct?

    Thanks for the comment πŸ’œ
    I was taking cypro, so removing that made me feel a lot better. I'm doing good! <3

  • source
  • parent
  • hideshow 1 child comment
  • Thank you! 🩷

    As for the timing, that is when my doctor prefers to test. He's my primary care doctor who primarily takes trans clients for primary care and hormone therapy.

    I do not know his reasoning, but I've been going to him for 3 years and he's the one who switched me to monotherapy. I believe he's more interested in the "average" level, rather than either extreme, as for most of the days you'll be closer to that than the peak or the trough. He factors the testing timing into determining what an appropriate level is, and he's stated that mine is slightly on the high end for what he finds acceptable, but as I feel good at this level, he's kept me on this dose since we got it dialed in about 3 years ago. Is it the best method? πŸ€·β€β™€οΈ I don't know.

    I do know this dose works much better for me than my previous provider. I had a lot of mood swings because they had me on a higher dose (10mg) on a longer interval (every 14 days instead of 7).

    I'm glad removing the cypro has made you feel better, and I'm glad you're doing good!

  • source
  • parent
  • [–] 3 points 2 days ago (2 children)

    Get your levels checked. Test at trough to ensure your T levels are never getting too high. And even then, always remember the golden rule of HRT: YOUR MILEAGE MAY VARY.

    Monotherapy works for some people; for others it doesn't. Some girls will just keep producing unacceptably high levels of testosterone regardless of how much E they take. It's exceedingly rare for girls to not experience any reduction in T after having E injections, but for some that reduction is just never enough to get T levels down into the cis female range. Or sometimes E alone can sufficiently suppress T production but not other androgens. There's a reason many girls experience a second wave of feminization after orchi.

    But reality check. A surge in libido, changes in bodily fluids, increased erections, these are clear indications of raising testosterone levels. Whether they're enough to be significant in terms of your overall body and physical transition? Unfortunately that's something that would take years to answer. But it's certainly possible; it's definitely not helping.

    Also, even if your levels are fine, don't be afraid to just go back on cypro if you can. Regardless of your levels, if monotherapy is making you feel subjectively worse than being on a blocker, then stay on a blocker. Now, if you're planning on never getting an orchi or SRS, at that point I might start worrying about the long-term effects of cypro use.

    If you're planning on needing to suppress testosterone forever, then suffering for a few months to iron out monotherapy is probably worth it. If you're planning on permanently nuking your testosterone production sometime in the next few years, then no reason to not just keep taking cypro until you get the snip.

  • source
  • hideshow 2 child comments
  • [–] [S] 2 points 1 day ago (1 child)

    You're...right. And to be honest, this comment convinced me to go back on cypro. I am planning SRS (as soon as possible), so I won't need to do this for my entire life. And honestly...the guarantee of suppressed T from cypro is worth it to me, even considering the downsides. I'm taking 25mg every three days now, which should, along with injections, be more than enough to keep my T nice and low. I'm really worried about "losing time on HRT" with an unsuppressed T level...

  • source
  • parent
  • hideshow 1 child comment
  • Yeah I get the fear of T levels. I really, truly get it. I've been on HRT since 2011, post-SRS since 2013. And on just E, my T levels are below the cis female levels. But if I want to supplement that T, I have to be very very careful, as since I'm post-op I'm obviously not taking any T blockers. Still, I decided to try it.

    For the better part of a year last year into this one, I decided to take some supplemental low-dose testosterone. I tried to give myself a very low dose, even using a custom-compounded low-concentration T vial to allow this. I had hoped to just raise my T levels back up into the cis female range, hopefully to improve energy, focus, etc. IIRC I was taking 0.25 mL of 50 mg/mL testosterone enanthate weekly, or about 12.5 mg/week. Typical trans guy dose is more like 50-200 mg/week. I thought I was being careful. I actually went to the trouble of getting a custom homebrew T vial made, just to make micro-dosing easier. Typical commercial vials are more like 200 mg/mL. These were compounded at a quarter of the normal concentration.

    But even on this low dose, when I tested my results, my T level was way too high. I did tests both at trough and the day after my shots, and I was at 322 ng/dL at peak, 75 ng/dL at trough. Still well below normal cis male T ranges, and at the same time I've had E levels that are above the typical cis female range. But I still had T levels well above the cis female range. I probably could have just kept fiddling with it until I found an acceptably tiny level of T to take, but I just gave up on it.

    Why? Because honestly, T just scares the shit out of me. I stopped taking it and haven't gone back. T may have given me a bit more energy and focus and made working out a bit easier, but it's just not worth the psychological trauma for me. Even if I can get some custom formulations that are lower concentration than the stuff trans guys use. Even if I can just lower my dose down to the point where bloodwork shows it's not a problem...this just isn't a fire I want to play with anymore. The prospect of remasculinizing is just such deep, fundamental, existential fear of mine, that I'm just done messing with it. I'll stick with my "below cis female" T levels at this point. I would rather be a little more tired than risk remasculinizing. And I wouldn't have any immediately visible signs of a problem like the return of erections, as I solved that particular problem permanently. πŸ˜‚ So if those high T levels are causing a problem, I won't realize it until I'm actually experiencing real significant remasculinization. I'm just done fucking around with this fire. It's just too dangerous.

  • source
  • parent