Even better if the aliens have no concept of a serial killer so they have no frame of reference for the horror they have brought upon themselves.

Terran

A serial killer wouldn't necessarily do well in this situation. They tend to get off on being sneaky and killing people with no way to defend themselves. A combat vet is probably their worst possible choice, which is why it's a popular trope.

If aliens were to abduct someone I'd think they would want someone who's alone and out of sight of most people. So it's probably going to be someone farther from the cities, and just walking by themself. So they might abduct someone out hunting, or they might abduct a someone hopped up on meth wandering through back roads or swamp areas of Polk County, Florida.

Either way, they probably got more than they bargained for.

Jurassic Park, but a future civilization of tiny beings tries to bring back various species of the Cenezoic Era, especially humans, among a few planets in a backwater star system . Chaos ensues. They lose control, evacuate, and slag the planets from orbit on the way out. Unbeknownst to them, a corrupt employee loses a vial of prokaryotes while trying to smuggle it out to a rival faction. It's smashed and washed into the sea in the process. The employee gets eaten by a frilled lizard. Billions of years later, that region of the galaxy is still quarantined. The descendants of the surviving prokaryotes look up at the stars hungrily from the surface of a tiny blue dot.

That's an Uno Reverse on the whole killer alien genre. I'd watch that in a heartbeat

Actual sociopath who has tried very hard to maintain boundaries and not commit crime even in secret suddenly finds himself in a safe space for venting.

Peak, must watch.

This could be done by fans overdubbing the movie Doom (2005). Add translation captions to all the monsters where they are friendly and confused but the sounds come out as Doom monsters.

Like Robot Chicken where they showed Panda Baba was actually a friendly architect and his friend was messing around by saying he was dangerous to ObiWan in the cantina.

Dexter: Green Blood

Call it... Slayer under Saturn.

S. U. S. For short

A part of that is in Predators (2010)

No One Will Save You.

Its about an outcast girl being caught up in an alien invasion except she is really good at killing them so much that i felt horror for the aliens.

I look forward too watching this in 10 years when Hollywood adapts it. Or in 2 years when someone slops it out as an ai vid

This is verbatim the plot of Jeremy Robinson's 30 Seven https://www.goodreads.com/book/show/242460569-30seven

Humans are space orcs.

Long as we’re listing horror movie ideas, here’s mine:

Sanewashing
Minor parody of modern politics. Begins as a creepy mysterious slasher movie about a man in a completely ridiculous clown costume slashing people up with little warning. A common theme is that no victims react as they should - frequently assuming they are amid a camera prank, or simply experiencing “sensory overload”.

While the movie follows one hero that is aghast and wants to explain the killings, other reactions are surprisingly mute - focused on mourning the deaths, not fearing any killer; and accepting the idea of a slasher in a clown costume as a stress induced hallucination.

Eventually, the hero is captured and the killer decides to give away the secret in a villain monologue: He’s just a serial killer who wanted to kill, but a random impulse made him decide on the clown costume - and it basically makes his existence stealthy, as though no one can acknowledge his very existence even when he barges in the front door.

sound of Hollywood execs calling Bob Odenkirk

There is a start trek voyager episode like this. It’s a great one. It’s called Meld, in Season 2.

May I suggest checking out the film "Get away" with Nick Frost and Ashling Bea.

Its absolutely excellent

This is kinda/sorta the plot of Alien, just with the species reversed. I love it. You could change the setup where the aliens respond to a distress call from a "Space Family Robinson in stasis" situation.

As a family man and not a serial killer, this would be an easy kill spree. Gotta get back before the wife calls in.

Humanity fuck yeah!

In a preemptive strike, aliens abduct 'the leader of the free world'.

I want to see this movie

...

Fuck, that's good.

Begbie* from Trainspotting

I mean the Web series deathworlders is not that but kind of is

Closest thing I watched was "no one will save you" Main character has to kill all kinds of aliens while they are tying to abduct her.

Minor spoiler:

It's a secret and he's in the closet about it.

This setup would have made me watch the Dexter reboot.

Are we the baddies Alien?

I’d watch this. Dexter vs Aliens.