I mean I definitely think it'd hurt him, but agreed on no crushing.

My problem is the spider sense logic. Even within the context of a joke, spider sense is clearly heavily temporal. I don't think, for example, that Spider-Man is constantly tingling over the eventual chronic illness he's going to succumb to in 50 years or whatever.

By the time his spider sense is going off, you're minutes if not seconds from finishing the compute and achieving the result anyway.

It may not even piss him off

The Green Goblin was there. Probably a Tungsten piano