The biggest initial issue for many is that it's pretty sedating, but that lessens with time. I slept like the dead for the first three weeks as baclofen is one of the few drugs that increases the frequency and duration of deep sleep. Now I can take 100 milligrams in a day and not feel a thing. I have literally no side effects.

One downside is sudden cessation is hell. If I miss an entire day, my anxiety gradually increases until it's through the roof until I start taking it again. Two days results in gradually increasing visual hallucinations. All of this completely reverses within an hour of taking a dose. You must taper off this stuff, but doing it isn't hard at all. Just don't go cold turkey.

It's also a medication that people tend not to grow resistant to. It hasn't lost any effectiveness for me despite having taken 60-80mg/day for almost two decades.

I used to have constant burning throat pain and the taste of stomach contents. Not anymore! It reduces the frequency of transient lower esophageal sphincter (LES) relaxation and increases its resting tone. Here's a relevant paper for anyone interested:

https://pmc.ncbi.nlm.nih.gov/articles/PMC9981648/

Bonus: 20 mg for non-users will halt hiccups but will likely also sedate them pretty hard. 10-20 mg will prevent MDMA hyperthermia.