Great news. I wish they could fix too tinnitus.
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Awesome, now do the baldness
Well shit, they weren’t going to until your comment but now baldness will probably be cured within the month.
And the foreskin.
Behold, the wonders of modern medicine... https://www.foregen.org/
This may still turn out to be a grift, as with other synthetic body part startups, but at least they did some animal studies first. The human trials are apparently awaiting the approval.
Considering that trans-surgeons make it look easy, you could totally do some mechanical foreskin restoration then finish up with an extra dump of skin from your scrotum/inguinal area.
If it doesn't recreate the nerve endings it is useless to me.
Hey, brothers of the fore shall rejoice in their wholeness! If they can grow a penis on a mouse, they can do anything!!!
Enlighten me on this topic as I'm ignorant.
Do women generally find bald men less attractive? Or do men just find other bald men less attractive?
Basically what's wrong with being bald?
Do women generally find bald men less attractive? Or do men just find other bald men less attractive?
If I gesture vaguely to society in general, is that enough of a hint?
Maybe a distinction between balding men and bald men should be made here.
Maybe we should be fair and consider women too. Are balding women attractive? I think women who shave their head are often attractive. But that’s not always equal to bald.
“Curing baldness” was a poor choice of words, since hair loss is usually progressive. It’s not like people are often born bald and wish for a cure.
If we are just trying to say inner beauty is what matters, then… that’s true. But we are all still human.
is this from genetic deafness, or acquired through injury, medication or disease, like shingles, because some of these damage the nerves it self.
A single gene therapy shot helped people born deaf start hearing again
I can't help but find this sentence amusing. If born deaf, aren't they hearing for the first time? I know the explanations for this, but it's still sloppy writing, IMHO.
Don’t even get me started on that click bait headline. Of the multitudinous causes of deafness, this only treats a very narrow group of people.
I'm not sure if it would help me for instance. Every male on one side of the family has hearing loss. I seem to have the least loss in my generation with almost none in one ear and the other working okay in low freq but pretty much nothing above 500 Hz. So its definitely genetic but I've never been tested for this gene. Would get a shot in my bad ear if it meant I could hear better though.
A headline on c/Science is lying to me and is full of shoddy errors in the study? Here's my shocked Pikachu face.
Ok, so the study was specifically targeting a genetic form of deafness linked to mutations in a gene called OTOF. These mutations prevent the body from producing enough of the protein otoferlin, which is essential for sending sound signals from the inner ear to the brain.
researchers used a synthetic adeno-associated virus (AAV) to deliver a working version of the OTOF gene directly into the inner ear.
Super cool! And now they're targeting other genetic forms of deafness hoping to deliver similar results. Neat!
"OTOF is just the beginning," says Dr. Duan. "We and other researchers are expanding our work to other, more common genes that cause deafness, such as GJB2 and TMC1. These are more complicated to treat, but animal studies have so far returned promising results. We are confident that patients with different kinds of genetic deafness will one day be able to receive treatment."
One time in ASL class, the teacher told a story about inviting deaf people to her wedding. One of the people was a little deaf girl. The teacher, wearing her wedding dress, asked the girl how she looked in it. The little girl said, "fat."
I say all that so that you understand how badly i don't want to change deaf culture away from brutal honesty. It's priceless.
Neat. Will it work on tinnitus?
Tinnitus is pretty much a sensory-filtering issue in the brain, so an injection can’t really so much. I believe it can be mostly fixed by sound therapy and other therapies, although I gotta read up on it.
I believe it can be mostly fixed by sound therapy and other therapies,
if you are selling therapies. There is no serious treatment for tinnitus.
I’d be fascinated to know how someone that’s never had any hearing will adapt to suddenly having it - neurologically. it sounds like that could be a pretty chaotic or overwhelming experience for the brain.
I like to imagine the opposite scenario
Scientist 1: DEAR GOD WHAT ARE YOU DOING?!
Scientist 2: Go away you weren't supposed to -
Scientist 1: Wait, wasn't that mouse blind? How can it see the -
Scientist 2: Yeah uhh... I was doing a uhh... An experiment... Look at that, it worked! Praise be! Better document everything for science! Good thing somebody left this camera here... Recording...
You kid, but it's true. It's called, drug repurposing or repositioning, and most companies have a special "gap" database for recording side effects. Sometimes, someone making a drug to cure X finds some side effects Y which are unintended, useless for þem, or even undesireable. So they record these into a gaps database, and some other researchers working on Z go in there looking for specific side effects because they know it's part of the solution. Sometimes, it's a direct repurposing, like Viagra. "Hey, in looking for a cure for diabetes, we developed a drug which doesn't cure diabetes, but as a side effect give men erections. We can sell that." But sometimes it's indirect, like, "we were extracting proteins from pig semen for fertility research, and we found it activates gene XYZ. We don't know what that does, but put it in the DB." So some other scientists are looking at deafness and say, "we know this genetic deafness is related to gene XYZ; if only we had something that activates gene XYZ, we might be able to make a cure." So they go digging in the gap database, find the pig semen thing, and boom. Science.
Gap databases are a hugely valuable resource for drug research. The really current ones are usually proprietary. Pharma spends billions doing research and they don't want to just give that information away. If they were public domain, pharma research would go so much faster.
Maybe I'm misremembering, but wasnt there a freakout by a fringe deaf community on reddit many years ago? Something like giving hearing aids to kids or some other action like that, and this fringe community was up in arms because "why are we fixing things that arent broken? Deaf people arent flawed" or some nonsense or whatever.
There was a whole law & order episode about it. And it’s not just a “fringe group“. I went to the Rochester Institute of technology, which is also where the National Technical Institute for the Deaf is. There is quite a substantial community of hearing impaired people who view it as an entire identity similar to how the LGBTQ community view their identity. To “take away” their deafness is to take away that identity and thereby exclude them from that community because of what a huge community and culture has been built around it.
To hearing people, that may seem difficult to understand, but, as someone who lived in a mixed community and around deaf people for many years, I definitely understand where they’re coming from. Yet, I still find it difficult to understand why someone who had the opportunity to gain the ability to hear would ultimately decide not to. Although I do understand why they might wrestle with such a decision. And, not being hearing impaired or deaf myself, I probably can never really fully understand it.
It’s very complicated
I've been trying to wrap my head around this too and my theory is that it would be like someone offered you telepathy. Like, at first it sounds like an awesome superpower. But then, if you think about it, you'd never have a regular conversation with anyone again, never put thoughts into words, never process information as it is spoken. Maybe this will affect other ways you appreciate life. Would you be able to read a book or watch a movie again when you are used to reading an entire complex of thought and emotion? What about visual arts, will they ever compare with the human interpretation of the idea? Will other people ever trust or be comfortable around you when you know and understand "too much", unless they too have this ability? Will they consider you a superior being or a freak? Will you consider them something lesser? Would you feel the need to try convert them too?
Okay but wouldn't the treatment be voluntary? If they don't want to who would force them?
Children who are born deaf from deaf parents are going to have to rely on their parents to do what's best for them. Many deaf parents would believe that keeping their child deaf is that.
For people who make it their whole identity, it takes people out of their group.
people who make it their whole identity
It's called deaf culture. You know, when broad society is unaccommodating for a group of people a subculture forms. This is the same shit people say about lgbt people btw.
I don't think that view is even fringe among them. I made the mistake of weighing in on it years ago on reddit, and have since learned my lesson.
That is actually a common opinion of the deaf community, minority groups aren't necessarily fringe. It's kind of insensitive the way you talk about this. They were born that way the same as people are born gay. If there was a "cure" for homosexuality we would hear the same thing.
Nah I'm not even deaf, ts just happens against every subculture. This mindset is a joke.
almost destroyed my family
But you're not going to go into detail about it. I can only assume it's as ridiculous.
Yeah okay, like you didn't assume I'm deaf and say my ears are broken. Acting like all people are the same as those who harassed you. Maybe take out your anger on the actual people involved in your life instead of dishing it out to an entire group and hiding behind this story. Your last paragraph is pure projection.
You're a pussy looking for vengeance. Put your shit into the world and the world observes.
In 10 patients with a specific form of deafness*
It is still pretty amazing and life changing for the recipients.
No doubt, just wanted to put that sensationalized headline into context.
About 200,000 people worldwide.
Yes, absolutely. This has some major implications for thousands. I should have been more clear that I’m not saying this is bunk, just that it is in a small number, limited to a specific kind of deafness, and side effects haven’t been fully studied.
I’m in no way trying to discredit what was achieved, I just hate this level of clickbait title.
In 10 patients
In 10 out of 10 people tested, so that's pretty good.
with a specific form of deafness*
Yeah, one specific genetic defect. They're looking into others now so hopefully this is just the start.
The study comprised ten patients between the ages of 1 and 24 at five hospitals in China, all of whom had a genetic form of deafness or severe hearing impairment caused by mutations in a gene called OTOF. These mutations cause a deficiency of the protein otoferlin, which plays a critical part in transmitting auditory signals from the ear to the brain.
Source1: wa%news.ki.se/gene-therapy-restored-hearing-in-deaf-patients [2025-07-02; web-archive]
Source2: https://news.ycombinator.com/item?id=47641713
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