What I don't get is why it took them decades to figure this out. Why have they been giving us sugar substitutes without understanding what they have been doing to us? Why were these approved for use in the first place?

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[–] 357 points 11 months ago (15 children)
  • [–] 142 points 11 months ago (3 children)

    The real mvp right here, fuck headlines like this

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  • [–] 35 points 11 months ago (2 children)

    But if they just put it in the title, people won't click and get bombarded with ads! Think of the big corporations!

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  • [–] 22 points 11 months ago (6 children)

    But…isn’t sorbitol a laxative??

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  • [–] 10 points 11 months ago* (3 children)

    all the -tols are laxatives, you heard ethyrthiol, i think its one of the potent ones that cause laxative effects the most. i heard tons of people were getting cramps or diarrhea for people who sensitive. some people are mildly affected by it, and some has no effect.

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  • [–] 2 points 11 months ago (3 children)

    I've never even seen this in any food. Think I'll be okay.

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  • [–] 4 points 11 months ago (1 child)

    The article calls it "common", but I've only seen it in a single brand of low-carb ice cream. I've actively sought low-carb options for over a decade. It's even less common than xylitol.

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  • [–] 34 points 11 months ago (2 children)

    Copied from another posting of this article:

    The headline (and the article for that matter) are very sensationalist and I don’t think they’ve presented this in a balanced way. They are discussing how sorbitol behaves in zebrafish with limited data presented on human biochemistry, and they discuss it in a vacuum without quantifying the amount of sorbitol it takes to cause a problem. Yes, any substance in excess can be harmful, but the amount of sorbitol in food compared to the amount of high fructose corn syrup makes it the substantially lesser evil. The artificial sweeteners are vastly more potent than actual sugar, so you don’t need very much of it to get the same amount of sweetness. High fructose corn syrup is used in massive amounts in food and is much worse for you on the scale that either substance would be consumed.

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  • [–] 4 points 11 months ago

    There's a whole cycle of perverse incentives with University Press.

    The underlying research is necessary and valuable but the marketing arm of universities blow everything out of proportion.

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    [–] 89 points 11 months ago

    Sorbitol-degrading Aeromonas bacterial strains convert the sugar alcohol into a harmless bacterial byproduct.

    “However, if you don’t have the right bacteria, that’s when it becomes problematic. Because in those conditions, sorbitol doesn’t get degraded and as a result, it is passed on to the liver,” he said.

    Pretty big caveat but the sensationalist headline is all people will see.

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  • [–] 23 points 11 months ago

    The article doesn't read as very concerning. Too much of anything usually means bad. Under the right conditions anything can be bad. Figuring out what can be bad and when it can be bad can often take decades. Don't stress too much on trying to optomize out anything that can do you harm in a diet. You'd have nothing left to eat and even the greatest collective of biologist getting together to make the greatest nutritional shake meal replacement would probably miss something that causes issues decades down the line or people drink too much and overdose

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  • [–] 15 points 11 months ago

    Phew! Thank God I'm not a zebra fish, otherwise I'd need to seriously reconsider my diet high on sorbitol.

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  • [–] 61 points 11 months ago (11 children)
  • [–] 12 points 11 months ago (7 children)

    Comments like this are ignorant to evolution. Zebrafish are an extremely powerful model for drug development and toxicology.

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  • [–] 10 points 11 months ago (4 children)

    You are obviously correct.

    Nonetheless, the headline doesn’t even hint at the YEARS of research required before this becomes something people should worry about.

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  • [–] -5 points 11 months ago* (3 children)

    What? I’m saying most research translates to humans and therefore people should cut back on sorbitol immediately or risk liver damage. Especially since people have very poor diets and do not maintain healthy gut flora. Are you seriously taking the stance that we should ignore this study and consume sorbitol? You first.

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  • [–] 8 points 11 months ago* (2 children)

    Maybe

    Half baked (well done, but incomplete) research has said:

    -Eggs are dangerous to eat

    -Saccharine causes bladder cancer

    -Smoking is good for colds

    -The way to lose weight is to eat a low fat high carb diet.

    Maybe not

    Part of science is recognizing how strong your data are and not generating hysteria after every research paper.

    What REALLY sucks is that we can no longer rely on the CDC and NIH to make recommendations.

    So you are free to cut sorbitol out of your diet and it may turn out to be a good choice. If that change makes you and others obviously healthier, I am sure this research will be repeated and expanded and soon we will all look back and remember having had your opinion.

    Edited formatting for readability

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  • [–] 5 points 11 months ago

    Zebrafish are an extremely powerful model for drug development and toxicology.

    Sure. But there's also a reason we don't do in silico molecular dynamics, test toxicology on zebrafish, and boom done drug is on the market. Even extremely close organisms, with LCAs much earlier than the zebrafish, can have wildly different reactions to potential drugs and dietary elements.

    There are things you can feed a chimp but not a human.

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  • [–] 11 points 11 months ago

    Tbh I am betting that it's gonna come out that they've known about the health risks all along, but they tried to ignore/cover it up for profit reasons.

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  • [–] 3 points 11 months ago

    Give up sugar. Try it, and tell me it isn't addictive.

    Give up all sweeteners, because keeping them just makes you crave more, making it much harder.

    I gave up sugar, and most fruits except berries. It made staying at my ideal weight MUCH easier. I really don't need to think about it, I weigh myself every few weeks, and I'm always at my ideal weight. Exercise is the other part of the equation, I think we need to do both.

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  • [+] -15 points 11 months ago (20 children)

    I’m not sure why people expected all these sugar substitutes to be harmless

    The entire notion of sugar substitution in the first place should be such an insane concept to everyone but somehow we’ve instead created a diet soda and junk food entitlement

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  • [–] 15 points 11 months ago (14 children)
  • [+] -9 points 11 months ago (13 children)

    It is if you don’t eat too much

    But aspartame will literally damage the DNA in your colon because it’s inherently genotoxic to our cells

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  • [–] 15 points 11 months ago

    The DNA damage comes from the formaldehyde that the body produces when metabolizing aspartame, but guess what? The body makes formaldehyde anyway, just from its natural metabolic processes. As long as you don't consume too much it's fine.

    The problem is over-consumption, which is the basis of having a consumer economy. If everyone ate less the food industry would collapse. They need us to overeat and if we ever stopped they'd have to reconcile with the fact that they can't just keep growing their profits infinitely. Plus, when we overeat, they can make even more money by treating the sicknesses it causes. Win/Win!

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  • [+] -10 points 11 months ago (11 children)

    Don't consume either. Artificial sweeteners are UPFs and sugar in all its forms have no place in the human diet.

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  • [–] 24 points 11 months ago (9 children)

    If you remove sugar in all its forms from your diet then you'd better forget about eating any plants whatsoever. Cellulose is sugar, carbs are sugar. Where do you think we get our energy from?

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  • [+] -7 points 11 months ago (8 children)

    Amino acids and fat. Why do we need sugar? It's not an essential nutrient.

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  • [–] 4 points 11 months ago (5 children)

    Lipids (fat) also gets converted into glucose before your body can use it. If we're cutting out sugar in all forms then that counts too.

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  • [–] 0 points 11 months ago (4 children)

    That is also my understanding. We needn't consume any exogenous sugars in any form, since the body is able to make all it needs.

    If we’re cutting out sugar in all forms then that counts too.

    That's nothing near to what I said. To reiterate my statement, there is no requirement for sugar in the human diet.

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  • [–] 1 point 11 months ago (3 children)

    Your previous comment definitely says "sugar in all its forms"

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  • [–] 0 points 11 months ago (2 children)

    Yes, in the human diet. Fats are not a form of sugar.

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  • [–] 1 point 11 months ago (1 child)

    Except it is, fat is how we store sugars. Lipids are made from glucose. It is sugar just in another form. If you eat glucose it gets turned into lipids and if you eat lipids it gets turned into glucose. All of our energy comes from turning food into glucose. You couldn't survive if you didn't have some form of sugar in your diet.

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  • [–] 0 points 11 months ago* (last edited 11 months ago)

    I'm not sure what to say to that. Are you asserting that fat is a form of sugar? I don't believe that to be case. One of the obvious differences is that sugars are water soluble, but fats are not.

    Triglycerides do contain a glycerol backbone, but aren't sugars. In any case I will revise my statement. Don't eat carbohydrates, get your nutrition from protein and the associated fat.

    Edit:

    All of our energy comes from turning food into glucose.

    In lipolysis, our bodies break down triglycerides into both fatty acids and glycerol. Most of our cells are also able to metabolize fatty acids for energy, not just glucose.

    You couldn’t survive if you didn’t have some form of sugar in your diet.

    Unless we conflate fat with sugars, it is perfectly possible to survive (and indeed thrive!) without eating any form of sugar at all. Again, the human body is capable of making all the glucose it needs.

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  • [–] 8 points 11 months ago

    Is your objection to substitutions? Because that's a very arbitrary line. Why is it that we call sorbitol a sugar substitute instead of calling sugar a sorbitol substitute? Grind up some plums to make juice, remove the sorbitol, add some sucrose in its place. Doesn't sound all that different.

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  • [+] 7 points 11 months ago (2 children)
  • [–] 2 points 11 months ago (1 child)
  • [+] -6 points 11 months ago (1 child)

    Oh who fucking cares? Everything we eat and breath is poison now. There is no saving anyone anymore.

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  • 17 comments in c/science@lemmy.world view that post
    [–] 78 points 11 months ago (1 child)
  • [–] 24 points 11 months ago

    What I don’t get is why it took them decades to figure this out.

    Well that's how it works with just about everything in high-tech capitalism. Enterprise & profits first, downstream and knock-on effects examined later. Just look at plastics, nicotine, pesticides, etc etc.

    I also tend to think that sorbitol and other replacements aren't necessarily terrible in themselves, but look at the way they're used-- a typical diet drink / food item doesn't attempt to lower overall sweetness levels, it attempts to replace almost 100% of the sweetness with the artificial product, killing much of the point of doing so.

    The good news is that consumers can be trained and untrained over time to crave excess sugars, salt, fat, fried food, etc. So you can reprogram your tastes over time, and get used to vastly lower quantities of unhealthy substances. For example, I used to drink and get normalised upon store-bought iced teas, which contain drastic amounts of sucrose / corn syrup. I just make it myself now, using a single packet of sucralose and a single sugar cube (15 kcals) in about 28fl oz brewed tea (Gatorade bottle). It took time, but it tastes perfectly sweet now, to me.

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  • [–] 47 points 11 months ago

    Pretty click-baity. They found out sorbitol was one step from fructose, which the researchers are actually studying

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  • [–] 26 points 11 months ago (4 children)

    The headline (and the article for that matter) are very sensationalist and I don't think they've presented this in a balanced way. They are discussing how sorbitol behaves in zebrafish with limited data presented on human biochemistry, and they discuss it in a vacuum without quantifying the amount of sorbitol it takes to cause a problem. Yes, any substance in excess can be harmful, but the amount of sorbitol in food compared to the amount of high fructose corn syrup makes it the substantially lesser evil. The artificial sweeteners are vastly more potent than actual sugar, so you don't need very much of it to get the same amount of sweetness. High fructose corn syrup is used in massive amounts in food and is much worse for you on the scale that either substance would be consumed.

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  • [–] 10 points 11 months ago (1 child)

    This is the correct comment. People are very quick to demonize food and food manufacturers, and I'm not saying they aren't making money on stuff that could be bad for us, but my understanding is that a lot of food additives that people worry about have been proven safe at reasonable consumption levels.

    We are not zebrafish! Usually, anyway. And no dose info? Suspect.

    Water will kill you if you drink too much of it. Everything in moderation!

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  • [–] 4 points 11 months ago (1 child)

    As it turns out when you overload your liver your liver is overloaded.

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  • [–] 4 points 11 months ago

    It's quite hard to actually overload your liver with the artificial sweeteners unless you are drinking literal gallons of zero sugar pop a day or eating nothing besides artificially sweetened foods. The stuff is used in such tiny concentrations that someone would have to deliberately seek out overdosing on this stuff to get the same effects as the experimental animals are getting (because the experimental animals are being fed pure sorbitol in doses that no human could reasonably consume.)

    That's the problem with articles like this is that they don't emphasize that they are only seeing this in animal models and they don't disclose just how much of the stuff they had to give to the animal for the negative effects to occur. It's also a bad study because it doesn't account for the differences in the physiology and biochemistry between humans and zebrafish, nor does it account for the confounding factors in humans. You know who drinks and eats a lot of artificially sweetened things? People with diabetes and people who are trying to lose weight. These are people that are likely to already have fatty liver disease and the sorbitol didn't really have much to do with it.

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  • [–] 18 points 11 months ago (4 children)

    Well, sorbitol makes you shit like the devil's own firehose, so if anyone thought it was totally fine they were probably not paying attention.

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  • [–] 8 points 11 months ago (3 children)

    After a certain age you may opt hor whetever moves it through ya

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  • [–] 4 points 11 months ago (1 child)

    Naturally occurring sorbitol in prunes is what makes them a good laxative. And honestly, the extreme diarrhea from sorbitol isn’t related to what this article is saying is a potential health problem.

    But the amount of sorbitol needed to cause liver strain as described in the article is going to be more than the amount needed to cause diarrhea, so it seems like a moot point.

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  • [–] 3 points 11 months ago

    A decades long double blind controlled study is FAR beyond the GRAS standard that requiring it would stifle not only commerce but also science in general.

    That's why sometimes we don't see bad effects in food until decades later.

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  • [–] 3 points 11 months ago

    Hm, Western populations under Capitalism - especially Americans - is nothing but forced guinea-pigs. Our health are for sale, and we get cheated at every step of the way. Capitalism absolutely sucks, is nothing but manufactured consent/100% corruption, and it's incredible that people still get so easily propagandized to believe in the plutocrats pet ideology/religion.

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  • [–] 2 points 11 months ago

    But Stevia is still save?

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