It’s sorbitol.
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The headline (and the article for that matter) are very sensationalist and I don’t think they’ve presented this in a balanced way. They are discussing how sorbitol behaves in zebrafish with limited data presented on human biochemistry, and they discuss it in a vacuum without quantifying the amount of sorbitol it takes to cause a problem. Yes, any substance in excess can be harmful, but the amount of sorbitol in food compared to the amount of high fructose corn syrup makes it the substantially lesser evil. The artificial sweeteners are vastly more potent than actual sugar, so you don’t need very much of it to get the same amount of sweetness. High fructose corn syrup is used in massive amounts in food and is much worse for you on the scale that either substance would be consumed.
There's a whole cycle of perverse incentives with University Press.
The underlying research is necessary and valuable but the marketing arm of universities blow everything out of proportion.
Sorbitol-degrading Aeromonas bacterial strains convert the sugar alcohol into a harmless bacterial byproduct.
“However, if you don’t have the right bacteria, that’s when it becomes problematic. Because in those conditions, sorbitol doesn’t get degraded and as a result, it is passed on to the liver,” he said.
Pretty big caveat but the sensationalist headline is all people will see.
The article doesn't read as very concerning. Too much of anything usually means bad. Under the right conditions anything can be bad. Figuring out what can be bad and when it can be bad can often take decades. Don't stress too much on trying to optomize out anything that can do you harm in a diet. You'd have nothing left to eat and even the greatest collective of biologist getting together to make the greatest nutritional shake meal replacement would probably miss something that causes issues decades down the line or people drink too much and overdose
Phew! Thank God I'm not a zebra fish, otherwise I'd need to seriously reconsider my diet high on sorbitol.
... In fish.
Comments like this are ignorant to evolution. Zebrafish are an extremely powerful model for drug development and toxicology.
You are obviously correct.
Nonetheless, the headline doesn’t even hint at the YEARS of research required before this becomes something people should worry about.
What? I’m saying most research translates to humans and therefore people should cut back on sorbitol immediately or risk liver damage. Especially since people have very poor diets and do not maintain healthy gut flora. Are you seriously taking the stance that we should ignore this study and consume sorbitol? You first.
Maybe
Half baked (well done, but incomplete) research has said:
-Eggs are dangerous to eat
-Saccharine causes bladder cancer
-Smoking is good for colds
-The way to lose weight is to eat a low fat high carb diet.
Maybe not
Part of science is recognizing how strong your data are and not generating hysteria after every research paper.
What REALLY sucks is that we can no longer rely on the CDC and NIH to make recommendations.
So you are free to cut sorbitol out of your diet and it may turn out to be a good choice. If that change makes you and others obviously healthier, I am sure this research will be repeated and expanded and soon we will all look back and remember having had your opinion.
Edited formatting for readability
...people used to think smoking was good for colds? Was it just menthols and the mint flavor?
Zebrafish are an extremely powerful model for drug development and toxicology.
Sure. But there's also a reason we don't do in silico molecular dynamics, test toxicology on zebrafish, and boom done drug is on the market. Even extremely close organisms, with LCAs much earlier than the zebrafish, can have wildly different reactions to potential drugs and dietary elements.
There are things you can feed a chimp but not a human.
Not at all, I'm just aware that this may not have any relevance to people, and right now it's little more than click bait fodder.
Do you think scientists start doing qualitative testing on humans first???
Tbh I am betting that it's gonna come out that they've known about the health risks all along, but they tried to ignore/cover it up for profit reasons.
Give up sugar. Try it, and tell me it isn't addictive.
Give up all sweeteners, because keeping them just makes you crave more, making it much harder.
I gave up sugar, and most fruits except berries. It made staying at my ideal weight MUCH easier. I really don't need to think about it, I weigh myself every few weeks, and I'm always at my ideal weight. Exercise is the other part of the equation, I think we need to do both.
I’m not sure why people expected all these sugar substitutes to be harmless
The entire notion of sugar substitution in the first place should be such an insane concept to everyone but somehow we’ve instead created a diet soda and junk food entitlement
Sugar isn't harmless.
It is if you don’t eat too much
But aspartame will literally damage the DNA in your colon because it’s inherently genotoxic to our cells
The DNA damage comes from the formaldehyde that the body produces when metabolizing aspartame, but guess what? The body makes formaldehyde anyway, just from its natural metabolic processes. As long as you don't consume too much it's fine.
The problem is over-consumption, which is the basis of having a consumer economy. If everyone ate less the food industry would collapse. They need us to overeat and if we ever stopped they'd have to reconcile with the fact that they can't just keep growing their profits infinitely. Plus, when we overeat, they can make even more money by treating the sicknesses it causes. Win/Win!
Don't consume either. Artificial sweeteners are UPFs and sugar in all its forms have no place in the human diet.
If you remove sugar in all its forms from your diet then you'd better forget about eating any plants whatsoever. Cellulose is sugar, carbs are sugar. Where do you think we get our energy from?
Amino acids and fat. Why do we need sugar? It's not an essential nutrient.
You don't understand human biology very well.
Lipids (fat) also gets converted into glucose before your body can use it. If we're cutting out sugar in all forms then that counts too.
That is also my understanding. We needn't consume any exogenous sugars in any form, since the body is able to make all it needs.
If we’re cutting out sugar in all forms then that counts too.
That's nothing near to what I said. To reiterate my statement, there is no requirement for sugar in the human diet.
Your previous comment definitely says "sugar in all its forms"
Yes, in the human diet. Fats are not a form of sugar.
Except it is, fat is how we store sugars. Lipids are made from glucose. It is sugar just in another form. If you eat glucose it gets turned into lipids and if you eat lipids it gets turned into glucose. All of our energy comes from turning food into glucose. You couldn't survive if you didn't have some form of sugar in your diet.
I'm not sure what to say to that. Are you asserting that fat is a form of sugar? I don't believe that to be case. One of the obvious differences is that sugars are water soluble, but fats are not.
Triglycerides do contain a glycerol backbone, but aren't sugars. In any case I will revise my statement. Don't eat carbohydrates, get your nutrition from protein and the associated fat.
Edit:
All of our energy comes from turning food into glucose.
In lipolysis, our bodies break down triglycerides into both fatty acids and glycerol. Most of our cells are also able to metabolize fatty acids for energy, not just glucose.
You couldn’t survive if you didn’t have some form of sugar in your diet.
Unless we conflate fat with sugars, it is perfectly possible to survive (and indeed thrive!) without eating any form of sugar at all. Again, the human body is capable of making all the glucose it needs.
Indeed, we should all be trying to reduce even sugar to 0
If there is a food Overton window it’s a solar system away from a normal diet
Is your objection to substitutions? Because that's a very arbitrary line. Why is it that we call sorbitol a sugar substitute instead of calling sugar a sorbitol substitute? Grind up some plums to make juice, remove the sorbitol, add some sucrose in its place. Doesn't sound all that different.
It takes decades to do the research or develop the issues
Genotoxicity of aspartame
https://pmc.ncbi.nlm.nih.gov/articles/PMC4235942/
Cancer risk of Erythritol
https://www.sciencedaily.com/releases/2025/07/250718035156.htm
https://www.health.harvard.edu/heart-health/sugar-substitutes-new-cardiovascular-concerns
Oh who fucking cares? Everything we eat and breath is poison now. There is no saving anyone anymore.
Sorbitol
What I don’t get is why it took them decades to figure this out.
Well that's how it works with just about everything in high-tech capitalism. Enterprise & profits first, downstream and knock-on effects examined later. Just look at plastics, nicotine, pesticides, etc etc.
I also tend to think that sorbitol and other replacements aren't necessarily terrible in themselves, but look at the way they're used-- a typical diet drink / food item doesn't attempt to lower overall sweetness levels, it attempts to replace almost 100% of the sweetness with the artificial product, killing much of the point of doing so.
The good news is that consumers can be trained and untrained over time to crave excess sugars, salt, fat, fried food, etc. So you can reprogram your tastes over time, and get used to vastly lower quantities of unhealthy substances. For example, I used to drink and get normalised upon store-bought iced teas, which contain drastic amounts of sucrose / corn syrup. I just make it myself now, using a single packet of sucralose and a single sugar cube (15 kcals) in about 28fl oz brewed tea (Gatorade bottle). It took time, but it tastes perfectly sweet now, to me.
Pretty click-baity. They found out sorbitol was one step from fructose, which the researchers are actually studying
The headline (and the article for that matter) are very sensationalist and I don't think they've presented this in a balanced way. They are discussing how sorbitol behaves in zebrafish with limited data presented on human biochemistry, and they discuss it in a vacuum without quantifying the amount of sorbitol it takes to cause a problem. Yes, any substance in excess can be harmful, but the amount of sorbitol in food compared to the amount of high fructose corn syrup makes it the substantially lesser evil. The artificial sweeteners are vastly more potent than actual sugar, so you don't need very much of it to get the same amount of sweetness. High fructose corn syrup is used in massive amounts in food and is much worse for you on the scale that either substance would be consumed.
This is the correct comment. People are very quick to demonize food and food manufacturers, and I'm not saying they aren't making money on stuff that could be bad for us, but my understanding is that a lot of food additives that people worry about have been proven safe at reasonable consumption levels.
We are not zebrafish! Usually, anyway. And no dose info? Suspect.
Water will kill you if you drink too much of it. Everything in moderation!
Ah, yes! Food!
https://www.youtube.com/watch?v=YkphooryVyQ
It's a hard watch so click at your own peril.
As it turns out when you overload your liver your liver is overloaded.
It's quite hard to actually overload your liver with the artificial sweeteners unless you are drinking literal gallons of zero sugar pop a day or eating nothing besides artificially sweetened foods. The stuff is used in such tiny concentrations that someone would have to deliberately seek out overdosing on this stuff to get the same effects as the experimental animals are getting (because the experimental animals are being fed pure sorbitol in doses that no human could reasonably consume.)
That's the problem with articles like this is that they don't emphasize that they are only seeing this in animal models and they don't disclose just how much of the stuff they had to give to the animal for the negative effects to occur. It's also a bad study because it doesn't account for the differences in the physiology and biochemistry between humans and zebrafish, nor does it account for the confounding factors in humans. You know who drinks and eats a lot of artificially sweetened things? People with diabetes and people who are trying to lose weight. These are people that are likely to already have fatty liver disease and the sorbitol didn't really have much to do with it.
Well, sorbitol makes you shit like the devil's own firehose, so if anyone thought it was totally fine they were probably not paying attention.
After a certain age you may opt hor whetever moves it through ya
Naturally occurring sorbitol in prunes is what makes them a good laxative. And honestly, the extreme diarrhea from sorbitol isn’t related to what this article is saying is a potential health problem.
But the amount of sorbitol needed to cause liver strain as described in the article is going to be more than the amount needed to cause diarrhea, so it seems like a moot point.
A decades long double blind controlled study is FAR beyond the GRAS standard that requiring it would stifle not only commerce but also science in general.
That's why sometimes we don't see bad effects in food until decades later.
Hm, Western populations under Capitalism - especially Americans - is nothing but forced guinea-pigs. Our health are for sale, and we get cheated at every step of the way. Capitalism absolutely sucks, is nothing but manufactured consent/100% corruption, and it's incredible that people still get so easily propagandized to believe in the plutocrats pet ideology/religion.
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