Many places are legalizing psychedelic mushrooms. MDMA is being used for veteran PTSD, and ibogane is gaining respect for severe addiction

I could see several forms of human genetic engineering becoming legal. For instance, three-parent children, also known as mitochondrial replacement therapy (MRT) is illegal in most western countries, though it was legalized in the UK, Spain, and Italy. The FDA banned in it in the US in 2015 because it involves human subjects research without prior approval from an institutional review board.

Cannabis. Possibly psilocybin.

In the US? Child labor.

Considering I'll be an old fecker in 50 years, I sure hope euthanasia is legal by then.

I will bet that a lot of genetic engineering restrictions in Europe will be more relaxed in 50 years than they are today.

The introduction of the car had people who were worried about it passing a lot of restrictions too; these went away over time.

https://en.wikipedia.org/wiki/Red_flag_traffic_laws

Red flag laws were laws in the United Kingdom and the United States enacted in the late 19th century, requiring drivers of early automobiles to take certain safety precautions, including waving a red flag in front of the vehicle as a warning.

In the United Kingdom, the law required self-propelled vehicles to be led by a pedestrian waving a red flag or carrying a lantern to warn bystanders of the vehicle's approach.

In particular the Locomotives Act 1865, also known as Red Flag Act, stated:

• Firstly, at least three persons shall be employed to drive or conduct such locomotive, and if more than two waggons or carriages he attached thereto, an additional person shall be employed, who shall take charge of such waggons or carriages;
• Secondly, one of such persons, while any locomotive is in motion, shall precede such locomotive on foot by not less than sixty yards, and shall carry a red flag constantly displayed, and shall warn the riders and drivers of horses of the approach of such locomotives, and shall signal the driver thereof when it shall be necessary to stop, and shall assist horses, and carriages drawn by horses, passing the same.

The Red Flag Act was repealed in 1896, by which time the internal combustion engine was well into its infancy.[1]

Slavery.

Legal for who?

In the USA, it'll become legal for corporations to fully own politicians and be treated as de facto nation states

Hopefully, soft cheeses.

Probably literal slavery instead of the Quasi slavery we have now. They're just going to cut out the middle man I think.

Bodily autonomy

Brutal execution of people committing "crimes".

Sexbots / Robotic Prostitution.

Might not be as advanced as in scifi, but...

Its more or less a perfect loophole for strip clubs.

Its not a person servicing you, you're simply paying for temporary use of mechanical equipment, like a gym.

Look at Cyberpunk 2077... Take your pick

In 50 years we're basically gonna be living in madmax. So everything is legal. Wild west baby

Modifying a 4d hypercube to embed it with perpetual catharsis and spiking someone's drink with it

Hunting the poor for sport.

Alternatively, hunting the rich for sport.

Punching Nazis

Violating laws.