Option 1) The honey nut squash vine itself will have a slightly prickly stem, the pumpkin will have a softer hairy-prickly vine skin and the cucumber will have relatively smooth vines (or the most prickly, depending on species of cucumber).
Option 2) Trellis all of it and if you notice any growing into a pumpkin shape, add a sling support tied to the trellis to hold the weight of the fruit.
Option 3) Just let them all ramble around and harvest what seems to be working out.