▲ 877 ▼ po-tay-toes (mander.xyz) submitted 7 months ago by fossilesque@mander.xyz to c/science_memes@mander.xyz 93 comments fedilink hide all child comments
[+] trackball_fetish@lemmy.wtf 1 point 7 months ago (1 child) [deleted] permalink fedilink source parent hideshow 1 child comment replies: [–] SoleInvictus@lemmy.blahaj.zone 3 points 7 months ago* (last edited 7 months ago) I'd agree if you weren't misquoting me and referring to another statement out of context. Do you have any specific criticism based on both what I actually wrote and actual medical science? Edit: I expect it's how I mentioned tricyclics as a first-line treatment. Within anti depressants, SSRIs/SNRIs > tricyclic > MAOI due to side effect profiles, but all will often (but not always) be trialed before moving to benzodiazepine monotherapy or higher dose/frequency adjuvant therapy. Some studies suggest TCAs are more effective than SSRIs. MAOIs are absolutely more effective than both, but their side effect profiles and restrictions due to dietary/medication interactions can be brutal. The greatest evidence for this cognitive damage is a self-selected Internet survey: https://pmc.ncbi.nlm.nih.gov/articles/PMC10309976/ We call that "pretty low quality" data in science and public health. Unsatisfied customers are more likely to write a review. lI'm not saying it's not possible, but actual data is scant. permalink fedilink source parent
[–] SoleInvictus@lemmy.blahaj.zone 3 points 7 months ago* (last edited 7 months ago) I'd agree if you weren't misquoting me and referring to another statement out of context. Do you have any specific criticism based on both what I actually wrote and actual medical science? Edit: I expect it's how I mentioned tricyclics as a first-line treatment. Within anti depressants, SSRIs/SNRIs > tricyclic > MAOI due to side effect profiles, but all will often (but not always) be trialed before moving to benzodiazepine monotherapy or higher dose/frequency adjuvant therapy. Some studies suggest TCAs are more effective than SSRIs. MAOIs are absolutely more effective than both, but their side effect profiles and restrictions due to dietary/medication interactions can be brutal. The greatest evidence for this cognitive damage is a self-selected Internet survey: https://pmc.ncbi.nlm.nih.gov/articles/PMC10309976/ We call that "pretty low quality" data in science and public health. Unsatisfied customers are more likely to write a review. lI'm not saying it's not possible, but actual data is scant. permalink fedilink source parent