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Unsurprisingly, those with faster gut transit times tended to have microbiomes dominated by faster-growing species that thrive on a high-carbohydrate, low-fat diet. Slower transit times, meanwhile, were sometimes dominated by species that thrive on protein.

Each of these extremes also had lower gut microbiome diversity than people with average gut transit times, suggesting that fast and slow movement creates environments where specialist species come out on top.

That would then create a feedback loop in which the dominant species in each environment releases metabolites that maintain the status quo.

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This may also help explain why the same gut health advice may not work for everyone. Two people can eat the exact same meal and get two very different results, depending on how fast their poop usually moves.

Transit times may even influence how your body responds to probiotics and certain supplements or medications that interact with the gut. This suggests that recognizing the individual gut rhythm of the patient could help tailor treatments and dietary advice that precisely matches their body.

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[–] 39 points 11 months ago (1 child)

Shorter transit times are associated with carbohydrate fermentation, leading to the production of beneficial short-chain fatty acids (SCFAs) that support gut health.

Longer transit times can shift microbial processes toward protein breakdown, potentially generating harmful compounds.

Not a one size fits all recommendation, but I suppose this is a silver lining to what feels like my stomach's near immediate reaction to food I eat ...

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  • [–] 24 points 11 months ago (6 children)

    Is it called poop when it's still inside your body? Wondering if this is a magma/lava situation.

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  • [–] 4 points 11 months ago (2 children)

    It's a large mass like a lumpy ball in your rectum. It's you asshole that shapes it into a log as it passes out.

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  • [–] 14 points 11 months ago (3 children)

    So how does this relate to people that are completely full of shit?

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  • [–] 19 points 11 months ago

    No shit.

    I'll see myself out.

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  • [–] 14 points 11 months ago (8 children)

    Your gut biome is probably going to reflect your diet, not the other way around

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  • [–] 4 points 11 months ago*

    It's likely multifactorial. Transit time is going to affect microbial composition at different stages of digestion due to resource limiting and nutrient transformation effects. The digestive system also directly affects microbial composition via the immune system and modulating nutrient degradation.

    I.e., two people with the identical diet and living identical lives could still have significantly different gut microbiomes.

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  • [–] 2 points 11 months ago (6 children)

    Pretty much. I greatly reduced carbs because the were making me feel like shit. Went from daily poops to twice weekly.

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  • [–] 8 points 11 months ago (3 children)
  • [–] 7 points 11 months ago (15 children)

    So I have a colonoscopy next month, and I’ll be doing that super cleanse before. Will that effectively reset my gut biome? Or would I need antibiotics or something else?

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  • [–] 10 points 11 months ago (13 children)

    No, it doesn’t reset it. And you wouldn’t want to kill off everything and start from scratch. The possible, maybe, shortcut would be a fecal transplant from someone with good gut flora.

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  • [–] 4 points 11 months ago (10 children)

    I’m really looking forward to the day this can be done with a simple prescription, a suppository of blended healthy samples, with a really long soft silicone applicator to get it roughly to the right area (I assume that’s kinda up in there). And is provided automatically after a round of antibiotics.

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  • [–] 6 points 11 months ago (1 child)

    People do it with homemade, swallowed capsules. (They dry it, blend it and pack it in capsules.) I’m not that brave.

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  • [–] 2 points 11 months ago

    The efficacy of shit transplants is what scientists call "controversial". Frankly, they never made sense as disease can alter the microbiome as much as microbiome can cause disease.

    It's being trialed for everything.

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  • [–] 4 points 11 months ago (2 children)

    with a really long soft silicone applicator

    I'm squinting at you really hard right now.

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  • [–] 2 points 11 months ago (4 children)

    Anyone on high dose antibiotics should be on a regimen of controlled diet and live culture probiotic supplements.

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  • [–] 2 points 11 months ago (3 children)

    But if you take probiotics and antibiotics at the same time they cancel each other out!!

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  • [–] 2 points 11 months ago (1 child)

    Do we know anything about what the gut microbiome does? Who's to say what's good for us or not until we know about health outcomes?

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  • [+] 1 point 11 months ago (4 children)
  • [–] 7 points 11 months ago (1 child)

    I read it more like the rate at which your body expels waste may signal what kind of microbiome you have in your gut. That microbiome may be more specialized and breaking down specific nutrients/fats/carbohydrates/whatever. Aiming to eat foods that are compatible with that diet, would be better for you.

    Each person is different so two people may eat the exact same meal, but the meal is “healthier” for the person who has the compatible microbiome.

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  • [–] 1 point 11 months ago

    A lot of the metabolic products of food digestion are carcinogens. If they don't flow out of your system, they can accumulate to dangerous levels. Modern processed fast food has little fiber and completely messes up the gut biome.

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  • [–] 1 point 11 months ago

    misread it as how long loop stays in your body

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