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Unsurprisingly, those with faster gut transit times tended to have microbiomes dominated by faster-growing species that thrive on a high-carbohydrate, low-fat diet. Slower transit times, meanwhile, were sometimes dominated by species that thrive on protein.

Each of these extremes also had lower gut microbiome diversity than people with average gut transit times, suggesting that fast and slow movement creates environments where specialist species come out on top.

That would then create a feedback loop in which the dominant species in each environment releases metabolites that maintain the status quo.

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This may also help explain why the same gut health advice may not work for everyone. Two people can eat the exact same meal and get two very different results, depending on how fast their poop usually moves.

Transit times may even influence how your body responds to probiotics and certain supplements or medications that interact with the gut. This suggests that recognizing the individual gut rhythm of the patient could help tailor treatments and dietary advice that precisely matches their body.

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[–] 7 points 11 months ago (15 children)

So I have a colonoscopy next month, and I’ll be doing that super cleanse before. Will that effectively reset my gut biome? Or would I need antibiotics or something else?

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  • [–] 10 points 11 months ago (13 children)

    No, it doesn’t reset it. And you wouldn’t want to kill off everything and start from scratch. The possible, maybe, shortcut would be a fecal transplant from someone with good gut flora.

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  • [–] 4 points 11 months ago (10 children)

    I’m really looking forward to the day this can be done with a simple prescription, a suppository of blended healthy samples, with a really long soft silicone applicator to get it roughly to the right area (I assume that’s kinda up in there). And is provided automatically after a round of antibiotics.

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  • [–] 6 points 11 months ago (1 child)

    People do it with homemade, swallowed capsules. (They dry it, blend it and pack it in capsules.) I’m not that brave.

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  • [–] 2 points 11 months ago

    The efficacy of shit transplants is what scientists call "controversial". Frankly, they never made sense as disease can alter the microbiome as much as microbiome can cause disease.

    It's being trialed for everything.

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  • [–] 4 points 11 months ago (2 children)

    with a really long soft silicone applicator

    I'm squinting at you really hard right now.

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  • [–] 2 points 11 months ago (4 children)

    Anyone on high dose antibiotics should be on a regimen of controlled diet and live culture probiotic supplements.

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  • [–] 2 points 11 months ago (3 children)

    But if you take probiotics and antibiotics at the same time they cancel each other out!!

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