sorted by: new top controversial old
he did that in c/lemmyshitpost@lemmy.world
I miss the days when THC didn't make me feel paranoid in c/tenforward@lemmy.world
[–] 5 points 2 months ago (1 child)

I brought up schizophrenia as your initial cited study mentioned the antipsychotic effect of CBD in people with schizophrenia, where you claimed that CBD is an antipsychotic.

The meta-analysis you've cited says that CBD does not consistently moderate the effects of THC across all outcomes and finished with a pretty lukewarm conclusion, that "CBD may interact with some acute effects of THC".

Here's another meta-analysis that also finds no consistent evidence that CBD improves the acute symptoms of THC: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30074-2/fulltext

My point being - the cannabis research field is not in a place to make any kind of concrete claims about CBD reducing the effects of THC. If it were, you'd see strong conclusions coming from meta-analyses, and cannabis companies wouldn't stop citing the research when promoting their balanced CBD-THC strains.

I don't think it's healthy to give people the advice that there is concrete evidence that CBD will make THC more enjoyable for them. There is no magic bullet that will make THC enjoyable for some people - although again, more power to you if it works for you.

  • permalink
  • fedilink
  • source
  • parent
  • context
    • I miss the days when THC didn't make me feel paranoid in c/tenforward@lemmy.world
    [–] 6 points 2 months ago (3 children)

    There is work from the same group of researchers showing that CBD + THC actually exacerbates the effects of THC on psychosis symptoms in people with schizophrenia: https://pubmed.ncbi.nlm.nih.gov/40702165/

    Plus I wouldn't be surprised if some of the beneficial effects of a gram of CBD on psychosis symptoms has to do with pharmacokinetic effects (CBD inhibits enzymes that metabolize a lot of drugs, meaning a gram of CBD in someone with Schizophrenia that is taking other medicines would increase their blood levels of the other medicines).

    Not to say playing around with some CBD is a bad idea if it works for you, but the actual hard evidence on CBD acting as a counter weight to THC's effects is pretty scant.

  • permalink
  • fedilink
  • source
  • parent
  • context
    • What are foods that a lot of people dislike but you like? in c/asklemmy@lemmy.world
    [–] 1 point 2 months ago

    Exactly this. I don't love it but I don't mind it. Some people really go out of their way to eat it every year. I'll eat it if it's offered.

    You just want a little bit of the fish, with lots of potato, onion, butter on a flatbread. It ends up just being a bit of umami.

  • permalink
  • fedilink
  • source
  • parent
  • context
    • I just.... wtf in c/whitepeopletwitter@sh.itjust.works
    Microsoft admits 8GB RAM is fine for Windows 11, after years of pushing 16GB as the baseline in c/pcmasterrace@lemmy.world
    Thai police disguise as dance troupe to arrest drug suspect, seize methamphetamine pills in c/nottheonion@lemmy.world
    Houseplant Trends in c/houseplants@mander.xyz
    [OC] "We won't go quietly. The Legion can count on that." in c/tabletopminis@lemmy.world
    Mashed potatoes in c/cooking@lemmy.world
    [–] 2 points 6 months ago (1 child)

    Thanks! Interesting to blend it with a hand mixer. I'll give this a try next time I make mashed potatoes. I usually struggle with some lumps left in the mix. I've tried making it with a potato ricer and then stirring in butter/salt. It turns out really nice and fluffy, but it's a pain to put so many pieces through the potato ricer lol.

  • permalink
  • fedilink
  • source
  • parent
  • context
    • Mashed potatoes in c/cooking@lemmy.world
    Plankton's army is marching towards the Strip in c/fnv@lemmy.world
    7
    Taper for 1 or 2 weeks for a semi-amateur runner? (lemmy.world)
     

    Hey everyone,

    I've been running somewhat seriously since about 2021, logging minimum 20 km/week year-round, and ramping up/down according to races. Last year I ran my first marathon and ended up bonking pretty hard at 30 km in. A tale as old as time itself. I wasn't following a training plan so I definitely didn't put in enough weekly kilometers to have a good aerobic base etc.

    Anyway, this year I'm following the Hanson advanced marathon training plan. I'm 9 weeks in (out of 18) and I feel like the cumulative fatigue is already starting to slap pretty hard. I'm working on slowing down the easy runs which is helping, and the last few weeks have also been quite hot and humid which isn't helping. I am also trying to ramp up my carb intake which has probably been a bit low.

    Anyway, my question - seeing as the advanced plan was probably a bit much to chew for my running level (going from 20-30km/week - 70-80 for the last 2 months), and I'm already feeling the fatigue, should I stick to the prescribed one week taper, or make it a two week taper? It seems like most plans generally have a two week taper.

    I was thinking about maybe doing one tempo run about two weeks before the race, then hitting 40-50 km that week, and the suggested ~30 km on race week. According to the training plan, the week before race week should be 86 km.

    view more: next ›