This is what I was hit with trying to visit r/Ketamine, Opiates, Stimson, Research chemicals etc etc all have the same. Obviously do not give your ID to reddit especially if you're visiting drug subs.

VHS cleaners. “Rush.” Etc.

These are very popular in the gay community, and pretty fun. They last a very short time but give a pretty intense euphoria when paired with other activities.

I skimmed through some webmd stuff but nothing was particularly concerning. Am I missing something? Are they harmless?

NeuralCIM is a version of erythropoietin (EPO) that only acts in the brain to increase a critical factor called BDNF, brain-Derived Neurological factor. BDNF promotes neo neurogenesis, new neurons to replace dying neurons in human brain. EPO is a very successful drug to promote red blood cell growth, but scientists knew the brain was full of EPO receptors, which have nothing to do with blood generation. If you give a patient too much EPO, their blood will dangerously thicken. See doping scandals in pro cycling early 2000s. But this version of EPO is taken through the nose right into brain, proven effective, just ask any cocaine addict.

The ATHENEA trial in 2023 concluded there was strong benefits of this drug in early-med Alzheimer, without severe adverse events. This is holding true since the trial, reported in 2025. This is in contrast to two US FDA approved Alzheimer drugs, Adumanucab and Leqembi, both of which have a high risk of inducing brain bleeding and death. Adumanucab has already been discontinued. Leqembi is US$400,000 a year per patient. The actual efficacy of Leqembi is "controversial". The cost of NeuralCIM: $25 for 10 doses. It is delivered intranasally.

So where are the media good news stories, why can't the world get this drug? Surely, at least one prominent American could use this drug.

The trick is in the name, CIM: Centro de Immuniologica Molecular. This is a Cuban research institute that famously developed a potent meningitis vaccine before anyone else. US Tourists are travelling to Cuba to buy this drug, prompted by US neurologists.

The caveat for ATHENEA was only 60 people in each test group, which established statistical significance over 4 years of trial, but the drug is now in the real world in Cuba and and we can expect large number data in a few more years.

It's a ironic that a treatment for Alzheimer is available only on an island under siege since 2025. We won't even go into why Adumanucab and leqembi were ever approved. BDNF is important for many neurological diseases.

cross-posted from: https://lemmy.world/post/50504433

Hi, my Dr. just started me on 10mg of Vyvanse, but I couldn't even feel it, so I tried taking 20mg yesterday morning, and I really felt that it made me more focused, slowed my mind down from racing thoughts, and made me more motivated. But I'm going back to 10mg today and talking to my Dr. about moving me up to 20mg on Thursday. What do you all think about Vyvanse?

My Dr. first started me on 15mg of Adderall XR, and I could not handle that. It came on too strong, lasted too long, made me clench my jaw all day, and made me jittery and nervous. Also, my Dr. has me on 0.5mg of Klonopin twice a day, but it's not really doing anything either. Back about 3 years ago, when I lived in another state, my psych Dr. had me on 2mg of Klonopin three times a day, and that did help.

But besides my ADHD, my real problem is anxiety and agoraphobia. I told my Dr. that sometimes I would take one of my mother's 2mg Xanax if I ever had to do anything in public or had an anxious situation. I told her I took one on our first appointment and that I was so nervous I almost cancelled our appointment 10 times leading up to it.

I also just sent my Dr. an email asking her if I could increase the Vyvanse to 20mg and the Klonopin to 1mg, but I have not heard back yet. I see her again Thursday, so maybe I shouldn't have sent her an email. I hate that I might be coming off weird, like I'm wanting more drugs, but that ain't it. I honestly can't even feel I've taken the dose.

But what do you all think about this, and what do you think about Vyvanse? BTW, this is the first time I've used Lemmy, first post ever on Lemmy, too, so please be easy on me lol. Thanks!

cocaine

bipolar in a powder

cross-posted from: https://lemmy.world/post/46674861

Greetings friends, and welcome to c/mdma!

This community has been shutdown / closed to new posts for 3 years for unclear reasons. It's now open to the public again!

c/mdma is now part of the c/drugs network of communities. c/drugs serves as the central Hub, branching off into more substance-specific discussions from there.

This also includes the establishment of some basic rules for this community:

Rules

(These rules apply across all communities in the c/Drugs network.)

No Sourcing - Do not request sources of any drugs at any time. This includes unregulated research chemicals. Any attempts, including "hit me up in DMs" type of requests, will result in a ban. This rule is necessary to keep this community open.

Harm Reduction - Do not recommend inherently dangerous doses or combinations of substances, or otherwise encourage behavior more risky than drug use already is by default. Clear attempts at causing intentional harm will result in a ban.

Avoid Dangerous Recommendations - Avoid recommending substances that have a reasonable chance of causing considerable harm to the user. For example, DPH, inhalants, or opioids. This rule is necessary to conform with Lemmy.World's Terms of Service. Posts violating this rule will be removed.

No Minors - Users under 18 years old are not permitted to use this community.

☺c/MDMA Rules☺

• Keep It Friendly - Be kind to your fellow humans. Disagreements, even impassioned ones, are fine. If you bring it down to the level of personal insults or excessive hostility, your posts may be removed. You may be banned in especially severe instances such as racism, sexism, Nazism, Zionism, etc.

It’s universally known that Kim Jong-un produces and distributes various substances and I could imagine that he also consumes.

While watching a documentary about North Korea, I imagined him having a really bad comedown on whatever he took and deciding “fuck it, scorched earth”, pressing the red button in a state of mania and sending nukes across the globe, resulting in an all out war against global forces, a one man army (and his military state), a captain sinking with his ship.

I should go to sleep, it’s 5am. :D

Horses getting personal again with a pretty wild story.

[P]lant scientists Paula Berman and Janka Höfer and their team set out to map and rebuild the biochemical pathways behind these compounds.

They identified the key genes used by two plants – Psychotria viridis and Acacia acuminata – to make DMT, and the step-by-step chemical pathways involved in producing the compound.

Then, they combined these with genes and pathways already known from psychedelic mushrooms (Psilocybe cubensis) and the cane toad (Rhinella marina), added supporting enzymes from rice and cress, then genetically introduced the combined genetic toolkit and kaboodle into tobacco plants (Nicotiana benthamiana).

The tobacco was chosen not because of its own drug production, but because it's basically the lab rat of plant species, with its fast growth.

Finally, the team carefully monitored the plant's production of five psychedelic tryptamines: DMT originally from plants; psilocin and psilocybin from mushrooms; and bufotenin and 5-MeO-DMT from toads.

The modified tobacco plants were found to produce all five compounds simultaneously. Because the different production pathways compete for the same resources, some compounds were produced in lower quantities than in their original sources.

However, the production was high enough to suggest that with a bit more tweaking, the system could function as a biological tryptamine factory for researchers.

I’m confused about caffeine pills.

Vivarin (200 mg), pic related and as of recent drug of choice works way better for me than off brand tablets. Feels like ~8 hours of energy. Then a big crash.

Tried many off-brand caffeine tablets, even double dose. Mostly just headaches though and not the same “clean” alertness.

I assumed quality control or additives or what not. But it’s literally just caffeine, right? Do other people see this? Could tablet fillers / how fast it dissolves matter? Or is this just tolerance + timing + placebo?

What’s the actual mechanism here?

Vivarin is the first time I understand why some people call it poor people's meth...

A “No-Veg” method flips plants straight to 12/12, trading smaller individual yields for higher annual output and a dramatic jump in top-shelf buds.

Abstract

This study revisits the hypothesis that Claviceps purpurea (Fr.) Tul., a fungus infecting cereals and producing ergot alkaloids (EAs), was the psychedelic agent in kykeon, the sacred elixir of the Eleusinian Mysteries. Although archaeological evidence supports this link, experimental data confirming the transformation of toxic ergopeptides into psychoactive lysergic acid amide derivatives in putative ancient preparations remain limited. The potential hydrolysis products of ergot were investigated using a technique that could have been readily applied by the priestesses of Eleusis, notably reacting in lye. Pulverized sclerotia were refluxed in solutions of lye and in distilled water. Samples obtained after liquid-liquid extractions were analyzed with 1H-NMR and UHPLC/Q-TOF-HRMS. The 1H NMR spectra demonstrated conversion of toxic ergopeptides, present in control samples but absent at all reaction times in 5% w/v ergot treated with pH 12.5 lye, where characteristic peaks for lysergic acid amide (LSA; ergine) and isolysergic acid amide (iso-LSA; isoergine; erginine) appeared. UHPLC/Q-TOF-HRMS quantitation confirmed this conversion, yielding 0.54 mg LSA and 0.48 mg iso-LSA per gram of ergot at 120 min. The chemical transformation of toxic EAs to psychoactive compounds, utilizing ancient technology, was demonstrated and supports the “psychedelic Eleusis” hypothesis.

Psilocybin was the most popular, followed (surprisingly) by Amanita muscaria, then MDMA, then LSD.

That means 3.7% of the American population has microdosed. If you ask me, we have to up those numbers, and those dosages... it's not a bad start, but I'm worried that it's a way to cheapen the psychedelic experience, lending it to "enhancing productivity" instead of rewiring your psyche and breaking down social constructs.

If it helps people, it can't be a bad thing. I just hope it doesn't stop at "micro" for most people.

What do you all think?

Recently I had COVID and as I powered through my headaches, I started to realize I was feeling a familiar smell - one that I had associated with being high on psychedelics.

As I thought about it, I realized more and more that it was the exact same smell, one that was deep in my trip memories. It isn't an unpleasant smell, just unique. And then I started thinking that COVID could be affecting similar parts of the brain as psychedelics and triggering a similar phantosmia (smell hallucinations).

I am wondering if this is something anyone else has noticed or was it just my own brain? Any comments?

This comprises 36 of the 182 psychoactives I self-administered for the writing of The Drug Users Bible.

Listed row by row:

• Methamphetamine, Xanax, Morning Glory Seeds, Heroin, Opium, Yopo Seeds

• 2C-B-Fly, 3-FPM, 1P-LSD, Hawaiian Baby Woodrose Seeds, Cannabis, Amphetamine

• GHB, Diazepam, Celastrus Paniculatus Seeds, Kratom, Psilocybe Cubensis Mushrooms, 2C-I

• MDMA, Pyrazolam, Noopept, Rapé, 2AI, Ubulawu

• Adderall, Etizolam, Kola Nut, Valerian Root, Cocaine, DXM

• Clonazolam, MXP, AL-LAD, San Pedro Cactus, Salvia Divinorum, Street Hash

The cannabis comprising the letter ‘P’ is gelato. The hash in the bottom right-hand corner is Moroccan.

This was always the plan. My book, all 638 pages of The Drug Users Bible, is now FREE to download as a PDF. To get your copy… please read this: =>

1. WHAT IS IT? In a nutshell, it’s a harm reduction reference tome. From Amazon: “Over a 12 year period the author of this book self-administered over 180 psychoactive substances; both chemicals and plants. For each he recorded the life-sensitive safety data, including the anticipated onset times, the common threshold doses, the routes of administration, and the expected duration of the experience. In addition, for every compound he also produced a trip report, detailing the qualitative experience itself. This delivered another invaluable insight, enabling, for example, an objective assessment of the extent of any loss of judgement and self-control.”

2. WHY IS IT NOW FREE? It was written to make a difference: to get critical harm reduction and safety data into the hands of as many people as possible, whatever their drug of choice.

The starting point was that I’m old and I like to read my books on paper. Hence, I wrote it for paper and always visualised it as the real physical book it became. That’s how it has always been sold, and still is. I know it has already helped a significant number.

HOWEVER, on paper it does cost $$$. I can’t change that, but what I can do, finally, is provide it for free as a PDF. So if you are happy with a non-paper version, and not too frustrated with this sort of navigation, you can now download it without charge.

You can have it on your phone, your PC, your laptop, or anywhere else you want it.

3. HOW YOU CAN HELP OTHERS It really is vital that we make harm reduction information ubiquitous within our community. It really is ignorance that kills so many of us. We really really must do our best as a community to make safety practices second nature, and get the essential data to everyone who needs it.

You can help with this project. Please do help.

If you are able, please download it and re-upload it to wherever is appropriate: to anywhere from which anyone who uses drugs may see it, and be able to download it themselves for free. Or alternatively just share the download link.

Ignorance kills, but I hope that some of you will help to save some of those lives. The portability of a PDF may help to at least put the idea of harm reduction on the agenda where it was previously overlooked.

4. WHERE CAN I GET IT? A complete and growing list of download locations, including the major cloud networks, is being maintained on the following page: https://www.drugusersbible.com/2018/01/pdf.html

As it is a drug book it could be removed by any of the clearnet hosts at any time, so it is probably a good idea to download it sooner rather than later.

5. FINALLY Thank you for any support you can give to this project. Together, let’s try to make a difference. If you have any questions, at all, please don’t hesitate to ask.

cross-posted from: https://lemmy.world/post/581350

At the height of my experimentation I had six drawers of different psychoactive botanicals running at once, plus a case for the bulky stuff. I’m not sure which are in each drawer specifically, but overall I sampled and documented the following (taken from the book’s contents page):

PSYCHEDELICS

Ayahuasca, Cebil, Chaliponga Leaves, Fly Agaric, HBWS, Iboga, Magic Mushrooms, Magic Truffles, Morning Glory Seeds, Ololiuqui, Salvia, Sananga, San Pedro Cactus, Sinicuichi, Syrian Rue, Yopo

STIMULANTS

Betel Nut, Coca, Ephedra, Ginseng, Green Tea, Guarana, Guayusa, Horny Goat Weed, Khaini, Kola Nut, Wormwood, Yerba Mate, Yohimbe

SEDATIVES

Blue Lotus, Cacao, Catnip, Chamomile, Damiana, Frankincense, Hops, Imphepho, Indian Warrior, Kanna, Lavender, Maconha Brava, Marihuanilla, Mullein, Mulungu,Passion Flower, Rhodiola, Saffron, St. John's Wort, Skullcap, Valerian Root, White Sage, Wild Dagga, Wild Lettuce

ONEIROGENS (DREAM HERBS)

Calea, Entada Rheedii, Mexican Tarragon, Mugwort, Ubulawu

DELIRIANTS

Datura, Nutmeg

UNCLASSIFIED

Cannabis, Kava Kava, Kratom, Mad Honey, Mapacho, Opium, Rapé, Sakae Naa, Tobacco.

As you would probably expect, many of these produced positive experiences; in fact some were astonishing in nature. Others however were relatively bland, with a few being truly horrendous, and indeed, traumatic.

Something I did learn early was that the need for a harm reduction process didn’t just apply to my chemical journey: due diligence and proper research are essential pre-requisites for all forms of psychoactive exploration. I burned myself too often. Stay Safe.

Since I can't seem to post on the drug gardening community I'll drop this here. Really digging the petal shapes on this one.

Bonus trichocereus bridgesii in the background.