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[+] 84 points 1 year ago* (last edited 9 months ago) (12 children)
  • [–] [S] 9 points 1 year ago

    Could it be the first one to pass this test phase?

    To study the safety of YCT-529 in humans, we conducted a Phase 1a clinical trial where 16 healthy men received either placebo or escalating single doses of YCT-529 to assess its safety and tolerability. YCT-529 was well tolerated, and no adverse effects were noted. The positive results from this first clinical trial laid the groundwork for a second trial, where men receive YCT-529 for 28 days and 90 days, to study safety and changes in sperm parameters.

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  • [–] 29 points 1 year ago (10 children)

    Female birth control has to be safer and have fewer side effects than pregnancy.

    Male birth control has to be safer and have fewer side effects than letting women carry the burden of birth control.

    There will not be a male birth control pill. We would be better off putting these resources toward improving the safety of female birth control.

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  • [–] 57 points 1 year ago (1 child)

    more options are always good for edge cases.

    1. some women can't take birth control pills, and the other birth control options have downsides as well.

    2. nothing is 100% effective, so if you want to be even more sure that you won't make babies, both pertners being sterlized is extra security.

    3. some men would like to be sterile but are hesitant to have a vasectomy done. They are generally simple but they don't always go well.

    4. for younger single men in casual encounters, you can never be sure of the other's birth control status. I'm sure there are men who would like the option to be in control of their sperm.

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  • [–] 15 points 1 year ago* (last edited 1 year ago)

    I’m not saying there shouldn’t be male hormonal birth control, it’s just that after 40 years of the same story over and over, it seems the effort should be redirected. Vasalgel has been “in development” since the 70s. It’s not getting any closer.

    Meanwhile, the US still only has one size of non hormonal IUD available, and two sizes of hormonal. They don’t fit most nulliparous women comfortably. This is a very fixable problem. 50 years of R&D could have solved this.

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  • [+] 25 points 1 year ago* (last edited 9 months ago) (2 children)
  • [–] 44 points 1 year ago

    It is a bit callous. I’m old enough to have seen this pop up a dozen or so times.

    Every time the depression, weight gain, acne and libido changes are deemed too severe for approval and women are sitting here like… yeah, it’s all that plus increased occurrence of stroke and heart attack for us, but ok.

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  • [–] 8 points 1 year ago*

    Callous or not, it's hard to justify trials ethically for that reason. Yes, it would be better for society as a whole, even if it could potentially be worse for an individual; but is it ethically right to burn up an individual for the sake of society? And now if you'll excuse me, I have to walk away from Omelas.

    Edit: Pre-empting a question: Yes, I walk. I recognize that the trolley would be quicker.

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  • [–] [S] 9 points 1 year ago

    Male birth control has to be safer and have fewer side effects than letting women carry the burden of birth control.

    This first phase study shows no side effect.

    It seems you are underestimating the value for men to not be responsible for unwanted babies and to have more control of their own contraception.

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  • [–] 20 points 1 year ago

    Male birth control has to be safer and have fewer side effects than letting women carry the burden of birth control.

    I mean, I don’t think this is such a high bar to pass.

    Pregnancy is bad but I’d argue the consequences of 18 years of unwilling parenthood far outstrips the consequences of 9 months of pregnancy. The consequences for those 18 years impact both parties.

    Furthermore, men have almost zero agency of what happens in the case of an unintended pregnancy. A man can’t say, “this would ruin my life, I am going to choose not to have the baby.”

    That makes the risk quite high for a man, IMO, and the only way to take agency over that risk is male birth control.

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  • [–] 12 points 1 year ago (2 children)

    Thing is, female birth control is easier, because female body already has mechanism that stops fertility, we just invoke it on demand. Male body basically keeps on making sperm till death. It's usually issues with erection or something that acts like "it's time to stop buddy" than anything else. It's not really about male privilege, patriarchy or whatever, it's just biology.

    Condom has worked the best as physical barrier and some injectable gels in vas deferens, but they are highly impractical application wise. Most of hormonal methods didn't work well at all.

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  • [–] 4 points 1 year ago (1 child)

    Nether method is more complicated or more natural or “easier.” It’s fiddling with hormones to decrease fertility.

    Your personal perception is that because when women are pregnant they can’t get pregnant, they should be the ones to have their hormones fiddled with, despite the risk of death, that has, thus far not been shown in male hormonal birth control. That’s got nothing to do with science.

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  • [–] 16 points 1 year ago*

    I'm sorry to call you out, but I think you're disregarding a valid point and establishing a false equivalence between this contraceptive method, and traditional hormone-based methods.

    Please let me elaborate. This drug is not hormone-based. It works by blocking a receptor called "RAR-alpha" that exists in every cell's nucleus, and it works as a switch that controls gene transcription - it determines what the cell eventually produces and does. The body chops up vitamin A and uses it to trigger this receptor, and we know that it plays a role in many different processes, from cell differentiation (including formation of the heart, nervous system, and white blood cells), to development (like the formation of limbs) and even cell death. Incidentally, it also plays a role in sperm production, which kinda makes sense because of how important it is for cell differentiation and development.

    The body doesn't produce a "blocker" for these receptors, which is the function that the drug in the study, YCT-529, performs. This actually mimics the loss of RARa signaling in a vitamin A deficiency, which unsurprisingly, causes fertility problems (among a host of other symptoms).

    This is a different approach from "traditional" hormonal contraception, where the most common pills (progesterone only or progesterone-estrogen) activate the same receptors that the body usually activates (and this is what the person above you was referring to) - but in way that prevents the regular cycle from progressing. The fact that the body has these "natural levers" that regulate this process is the reason why birth-control pills have existed for decades - we just push those buttons harder (I'm not denying there are consequences to this, I'm just pointing out the buttons exist). There is no such mechanism for sperm production however, so scientists have been looking at all steps that lead to sperm being produced trying to find something they can block, and that hopefully won't have terrible consequences elsewhere.

    I 100% agree that calling either method "more complicated" or "more natural" or “easier" is wrong. But we cannot gloss over the fact that this drug is a compound that is novel to the human body, and that it works through mechanisms that we only have a limited understanding over, while the other is inherently less risky (because most of its effects are to mimic the body's normal responses) and, at this time, much better understood.

    Hopefully this will prove to be a very safe and effective drug, and that responsibility for contraception is equally divided because of it, but this needs to be proven first.

    Also sorry for the wall of text, but it's kinda in my ballpark so I sort of ran with it.

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  • [–] 0 points 1 year ago* (last edited 1 year ago)

    Except there are many women who would like to get pregnant and trap the sperm doner into child support. I think many men would love to be in charge of their futures. Condoms can fail or be sabotaged.

    Edit: Downvote me all you want but in the name of equality there should be options for males to take if they want to give their female partners the choice not to take anything. Not saying women don't deserve better options but there should be options for males too.

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  • [–] 20 points 1 year ago (2 children)

    gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme gimme

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  • [–] 24 points 1 year ago (1 child)

    Imma just wait until they let me inject a boba ball into my nutsack.

    Reversable, safe, effective, no hormonal effects. Why would I fuck with a pill?

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  • [–] [S] 4 points 1 year ago

    Because this seems more invasive and according to the article, it was not yet peer reviewed.
    Every solution will have a different balance of risks and benefits, more choice is good.

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  • [–] 27 points 1 year ago* (13 children)

    itd be awesome if this was the secret to adult male dry orgasms. i would takr that like birth control without even needing that for sex specifcially.

    being able to do the deed without worrying about cleanup or pregnatizing anyone is the ultimate value

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  • [–] [S] 25 points 1 year ago (6 children)

    I don't think this stops liquid production, it just drastically reduces the sperm count, which is a small percentage of the ejaculation.

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  • [–] 3 points 1 year ago (3 children)

    If anyone can figure that out without needing to remove the prostate, that would be huge. Seems like thats the actual root of ejaculation or something to that effect

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  • [–] 1 point 1 year ago (2 children)

    I mean, you could inject say, 6 mg of estradiol enanthate weekly. That would produce dry climax for most people. Though, there may be some...undesirable side effects, depending on your perspective....

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  • [–] 4 points 1 year ago* (last edited 1 year ago) (1 child)

    I've heard there is already something that basically makes guys shoot dry blanks, search dry orgasm pill

    Uber-"straight" men should have no problem with that since they dont use it for anything 🙄

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  • [–] 3 points 1 year ago (1 child)

    hate to burst your bubble but this pill just reduces sperm count (which is only like 2-5% of ejaculate) - you'd still have all the same fluid, just without the swimmers in it.

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  • [–] 1 point 1 year ago*

    This one yes, but pretty sure I've read of another male dry orgasm pill where the study participants specifically complained about the lack of ejac. They sounded insane, if they were actually motivated purely by pleasure and convenience like they should have been, it makes no sense. They were probably basing that on cultural bullshit like "I'm a man, I shouldn't be dry orgasming, thats not what grown men do" or something. It seemed very culturally driven

    Dry is superior, you should be able to only cum when you want or need to, its a waste of micronutrients and some say lifeforce otherwise. Something somethint chromium rare nutrient nofap

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  • [–] 3 points 1 year ago*

    I mean you could take a 6 mg injection of estradiol enanthate weekly. That would produce the effects you want. Though...it...may also have some other effects...but anything's work it for a dry climax, right? 😈 😆

    /s for the dense.

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  • [–] 9 points 1 year ago (18 children)

    I feel like i could never trust this even if i was on it.

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  • [–] [S] 18 points 1 year ago (7 children)

    Would you trust it less than the female birth control pills?

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  • [–] 16 points 1 year ago (6 children)

    No. But I also dont trust female birth control pills. I'm vaguely aware of the side effects and hormonal shifts, and I don't think I want that in my life.

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  • [–] [S] 4 points 1 year ago

    The big point of this one is that it is not hormonal, and so far this study shows no side effects. So for a couple, it could be the pill with least side effects overall.

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  • [–] 4 points 1 year ago* (4 children)

    of course nothing is 100% effective, not even condoms. consider each an additional layer of security.

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  • [–] 3 points 1 year ago (2 children)

    Sure, but is the additional security worth the sides? I could wear a medieval suit of armor around all day to be safer, but it would be extremely inconvenient.

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  • [–] 10 points 1 year ago (9 children)

    Good! You shouldn't. If you're trying to not have children, you should be on birth control, or partner should be in birth control, and you should use condoms.

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  • [–] 2 points 1 year ago (8 children)

    I've been there done that, lol. I'm old and already did the contraception and condoms long ago. Have 2 children now, do not want more. It sounds like a nice alternative to snipping, but I just can't trust it. We are fine, and im sure menopause is not far away for her.

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  • [–] 5 points 1 year ago (3 children)

    It sounds like a nice alternative to snipping,

    Don't fear the snip.

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  • [–] -1 points 1 year ago (3 children)

    Don’t fear the snip. Mine was almost entirely painless and it’s really nice to have one less thing to worry about.

    Only side effect is now my right testicle dangles lower than my left.

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  • [–] 3 points 1 year ago* (last edited 1 year ago) (2 children)

    Agreed. I was hoping for vasalgel work out, got tired of waiting, and got the snip.

    There's lots of anecdotal evidence that orgasms are actually better afterwards. I tend to agree, but it's something that's easy hard to study properly. Edit: god, that was bad wording.

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  • [–] 10 points 1 year ago* (6 children)

    In the first clinical trial of its kind, a nonhormonal oral contraceptive that reversibly stops sperm production has just been deemed safe for human use....The trial did not assess the pill’s efficacy in reducing sperm

    Uh, lol...I have to admit, I'm not really going to start caring about whether it's safe until I know that it actually does what it's trying to do.

    How can you even honestly say it's a "contraceptive that reversibly stops sperm production" without qualification, if you haven't even determined it fucking works, yet?

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  • [–] [S] 29 points 1 year ago* (last edited 1 year ago) (2 children)

    This how medical studies work, because of ethics. First they prove it works on animals, which they did with great success. But before testing it works on humans, they must first confirm it is not dangerous, before they can ethically test for actual efficacy on a larger cohort.

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  • [–] -2 points 1 year ago (1 child)

    I understand that's the sequence of events, but, my point is that this isn't worthy of a headline, not yet.

    A safe drug that doesn't work doesn't matter. It only matters once it's proven safe and effective.

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  • [–] 6 points 1 year ago (9 children)

    Guys will do anything rather than cut off their own balls

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  • [–] 17 points 1 year ago (3 children)

    I'm pretty sure conservatives are mad that some men actually are.

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  • [–] -3 points 1 year ago (2 children)
  • [–] 6 points 1 year ago (2 children)

    Why would anyone in their right mind cut off their own balls?
    That's beyond Jackass levels and into the realm of Darwin awards.

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  • [–] 2 points 1 year ago

    Dude it's not even that. I got the snip, I was back rocking in the sack 5 days later. Kids mom at the time had to give me shit ton of BJs and hand jobs. Because even week later you can still have live sperm in your sack.

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  • [–] 0 points 1 year ago* (3 children)

    As long as Christians hold money and power this isn't ever coming out.

    But... want... :c

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  • [–] [S] 5 points 1 year ago (2 children)
  • [–] -3 points 1 year ago (2 children)

    This will just result in more republican births since they seem to think they are in some breeding war and won’t use it.

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  • [+] -16 points 1 year ago (6 children)

    Compliance ain’t gonna happen. Try getting a dude to take something regularly that isn’t a painkiller. Let’s mix it with advil.

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  • [–] 23 points 1 year ago (2 children)

    I dunno, I think "take this pill every day and you'll never have to pull out again" is a pretty convincing argument to that type of dude.

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  • [–] -1 points 1 year ago* (1 child)

    If this lets you jackoff totally dry as long as you take it, i cant see why any dude would not be all over that like white on rice. Its literally the dream

    Ejaculation sucks

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