The full quote:

“I hope we do more like cold opens that aren’t always political because those are just, like, fun to do,” Che added, noting, “I know how our bread is buttered.”

Doesn't sound like he's strongly against the political opens, he just enjoys doing other kinds.

It’s a variety program about American culture. You can’t do cultural commentary without doing politics, and when the state of politics is literally “will we decend into fascism or not thanks to a literal clown”, it’s not just buttering the bread, it’s the whole shebang. People would stop watching if you became a complacency distraction hour of boring dad jokes, or worse, far right “comedy” routines. The most popular thing he does is the routine with his white co-host where they literally use free speech and comedy fused to show how comedy is done right while being shocking, without punching down. It’s political. But it’s not hate. So leave the show and go write entertainment that isn’t political, or start buttering that bread with great interest.

I see content of stand up comedians doing crowd work more than anything anymore. Politics routines make people angry at them. The reactions went from, "haha it's true'. To full blown meltdowns.

It's like people are chasing hits of indignance. The same way social media trained us to chase quick hits of outrage per post.