Feed it to RFK Jr.
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It didn't answer the most important question which is, Are they pathogenic?
It did.
Psychrobacter SC65A.3 is a strain of the genus Psychrobacter, which are bacteria adapted to cold environments. Some species can cause infections in humans or animals.
If it’s not immediately obvious: The intended takeaway is that this particular strain probably isn’t pathogenic itself, but it’s completely plausible that such resistance can spread via HGT to pathogenic species, within the genus or not.
That didn't answer whether these particular bacteria are pathogenic.
It does to the target audience.
What you’re missing is that Linnaean taxonomy breaks down when discussing bacteria, and the line between strain/species doesn’t really exist.
Bacteria swap a lot of genetic material asexually, including across dramatically different species. Pathogenicity can also be dramatically modulated by presence of other species and environmental conditions.
The idea of a particular strain or species of bacteria being inherently pathogenic in a binary yes/no way is a surprisingly flimsy and unhelpful one.
I don't want to know if these bacteria are potentially pathogenic. I want to know if they're pathogenic.
How are you distinguishing those ideas?
Are we talking about “has actually been found infecting human patients”?
Yeah, I really didn't think that through. I guess we can't go testing them on random people.
Even if we ignore any ethical concerns, when you’re sampling from an extreme environment, the strains you’re finding will, with >99.9% certainty, have substantially diverged from a biologically identical ancestor that’s spent a fair number of generations infecting hosts.
So you also get a weird Ship-of-Theseus type question of “are these still really the same bacteria?”. And if you assume they are going to be different strains after adapting to different environments, then you can also safely assume that whatever strain you’re sampling in an extreme environment has a >99.9% probability of being in the potentially-harmful, contextually-harmful, or non-harmful bucket, by virtue of the fact you found it isolated in the wild rather than in living hosts.
To put it a little more simply: if you’re looking for something with a demonstrated ability to infect people, you’ll probably find that inside or nearby people, not in an icy, remote cave.
There is a huge number of bacteria that do absolutely nothing to humans.
Is this one of them?
It comes from a Cave at the northwest of Romania. So it may as well be a bacteria that turns you into a vampire or something...
Very shortly,
“Ancient Bacteria Resistant Against 10 Modern Antibiotics Accidentally Released From Research Facility”
Well fucking yeah. Leave it be.
The bacteria will eventually be revived in one way or another, and it's just hanging out around our poles right now. So getting information about the microbe seems like a better idea than waiting for it. Not only is it not anticipated to be a human pathogen (only 5/37 of known Psychrobacter species are pathogenic), but it may also contribute to the reduction of antibiotic resistance thanks to its ~600 novel genes.
“The researchers found almost 600 genes with unknown functions, suggesting a yet untapped source for discovering novel biological mechanisms. Analysis of the genome also revealed 11 genes that are potentially able to kill or stop the growth of other bacteria, fungi, and viruses.”
Nevertheless, BSL III & IV labs are remarkably secure. However, pathogenic psychrobacter is an opportunistic pathogen that requires an immunocompromised individual. So sure, it is not entirely risk-free, but the fact it's unlikely to be pathogenic and wouldn't be a significant issue if it were makes it worthwhile to uncover information about this ancient species. Especially if this research unveils new methods for killing other pathogens and having some breathing room regarding antibiotic resistance.
Climate change is melting permafrost everywhere, these things will be coming out, zero chance of us cutting emissions to make it not so.
This highlights the importance of studying ancient bacteria to understand the natural evolution of antibiotic resistance and ways in which those bacteria could be used for future medical and biotechnological solutions, the researchers said.


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