cross-posted from: https://lemmy.world/post/36298939

New research reveals that the DNA switches controlling human finger development originated from genes that regulated fish cloacas 380 million years ago[^1].

"Rather than building a new regulatory system for the digits, nature has repurposed an existing mechanism, initially active in the cloaca," explains developmental geneticist Denis Duboule from the University of Geneva[^1].

The research team discovered this by comparing fish and mouse genomes, focusing on Hoxd genes. When they tagged DNA switches with fluorescent markers, these lit up in mouse digits but in fish cloacas. Deleting these genetic elements using CRISPR-Cas9 disrupted finger development in mice and cloaca formation in fish[^1].

"The common feature between the cloaca and the digits is that they represent terminal parts," notes geneticist Aurélie Hintermann. "Sometimes they are the end of tubes in the digestive system, sometimes the end of feet and hands"[^1].

[^1]: ScienceAlert - Fish Buttholes May Be The Reason We Now Have Fingers, Study Finds

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[–] 40 points 1 year ago

Early contender for the 2026 Ig Nobel prize.

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  • [–] 22 points 1 year ago*

    Now it makes sense why they're called carpal joints, although I guess the metacarpal bones are closer to home on this one...but only the most anal would care about that.

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  • [–] 20 points 1 year ago (1 child)

    I swear, we gotta be part of some higher-level organism's weird science project

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  • [–] 14 points 1 year ago (1 child)

    i'm gunna get some weird looks at my next party....

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  • [–] 14 points 1 year ago

    Every butthole is a fingering opportunity

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  • [–] 14 points 1 year ago (1 child)

    I knew there was a reason my fingers are always drawn to them

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  • hideshow 1 child comment
  • Try finger but hole

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  • [–] 12 points 1 year ago (1 child)

    Let's take a moment to honor the uncountable horrors birthed oh so briefly into this world who's combinations of ass and appendage genes weren't so fortunate.

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  • [–] 12 points 1 year ago

    Fun fact: one of the earliest cell divisions after mammalian conception are the two sphincters that become the mouth and anus, with the latter being the first to generate. We're all assholes in the beginning. Some of us grow out of that.

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  • [–] 8 points 1 year ago (2 children)

    Wonder if this has implications for regrowing fingers.

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  • [–] 1 point 1 year ago

    Yeah no, fingers are for grabbing things that aren't salmon assholes actually

    Spiders Georg all over again smh

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  • [–] 1 point 1 year ago*

    So not "butter-fingers", it's actually "butt-fingers".

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  • 33 comments in c/science@lemmy.world view that post
    [–] 116 points 1 year ago (4 children)

    This is the best out-of-context headline I've read all month.

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  • [–] 46 points 1 year ago* (last edited 1 year ago)

    The Nature article in case you want to skip the pop science and get to the good stuff.

    Because Hoxd gene regulation in the mouse urogenital sinus relies on enhancers located in this same chromatin domain that controls digit development, we propose that the current regulatory landscape active in distal limbs was co-opted as a whole in tetrapods from a pre-existing cloacal regulatory machinery.

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  • [–] 38 points 1 year ago* (1 child)

    ⊂( ͡° ͜ʖ ͡°)☞ >-;;⁠;⁠;€ᐷ

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  • [–] 34 points 1 year ago (3 children)

    What a coincidence, a fish butthole is why I don't have fingers anymore.

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  • [–] 21 points 1 year ago (1 child)

    I would feel awful finding out I genetically modified a fish to not have a butthole.

    That’s fucked up.

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  • hideshow 1 child comment
  • That's a brand new sentence right there

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  • I love how so much science ultimately boils down to putting creatures in a giant magnet and seeing what lights up.

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  • [–] 6 points 1 year ago

    So when I was eating fish fingers as a kid in the uk, what was I really eating???!

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  • [–] 5 points 1 year ago (1 child)

    And here I thought me sticking my fingers up fish buttholes was the reason they existed.

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  • [–] 5 points 1 year ago

    So holding hands is obscene!

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  • [–] 4 points 1 year ago (1 child)

    Some people, in fact, still have hands growing out of their ass

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  • [–] 4 points 1 year ago (1 child)

    I'm looking at my fingertips .... realizing that they could have become something else.

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  • [–] 4 points 1 year ago

    That sounds like something AI would say

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  • [–] 4 points 1 year ago (1 child)

    Mmmmm, butterfingers are my fave.

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  • [–] 3 points 1 year ago

    Fish fingers and custard!

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  • [–] 3 points 1 year ago

    me walking in with 10 fish on my hands

    "OMG you're not gonna beleive this..."

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  • [–] 2 points 1 year ago

    I goatsee what you did there.

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  • [–] 2 points 1 year ago

    Buttfingerer

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  • [–] 1 point 1 year ago

    It's why I have fingers... ( ͡° ͜ʖ ͡°) 🐠

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  • 4 comments in c/science@lemmy.ml view that post
    [–] [S] 17 points 1 year ago
    [–] 11 points 1 year ago

    I was prepared for this to be a story about how we used to compare who could finger a fish the deepest and the winner got to mate with the girl and now I’m kinda sad but also really relieved.

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  • [–] 5 points 1 year ago (1 child)

    So just to be clear here.

    Scientists bread mice with no fingers to hunt food. Fair enough but poor mice.

    And fish with no arseholes, so they can eat but never crap.

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