They're unrelated, and to each other. That is, you could watch Edgerunners II before Edgerunners and it wouldn't matter. They're unrelated, as is the book V narrates the audiobook for. "No" something, I forget. And the game is unrelated to all of it.

Though, there are similarities. Edgerunners II starts with some gonks (idiots) stealing a computer chip from Arasaka, a corporation based in Japan. The game starts similarly. But they aren't the same story at all.

If anything, you might wanna hold off on the game until after the series, because the game has added elements of the series over time. You can find references and do things related to the series, which implies the series takes place before the game. But none of them spoil the others.

are you using RT?

on my system the game crashes when loading into the game (or running benchmark) with RT on. Worked fine a month or two before the patch, I have no clue if some other update (proton-ge/cachy, heroic, nvidia-open, arch in general...) did it. Logs seem to indicate something about nvidia & shader compilation (I don't remember the exact error atm).

If it crashes straight from launch, check if you have your mods updated, eg. red4ext (winmm.dll) is really crash-happy if it's version doesn't match the game's

edit: oh derr, you got it fixed? gotta check the protondb then as well.