cross-posted from: https://discuss.online/post/48201538

http://www.smbc-comics.com/comic/friendship-2

Alt textLater it turns out to be a gay bar, and things go better than expected.

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[–] 2 points 12 hours ago

Main Reasons Doctors Avoid Diclofenac

Cardiovascular Risks: Diclofenac increases the risk of serious heart attacks, strokes, heart failure, and blood clots at a rate comparable to specialized COX-2 inhibitors (like rofecoxib). Studies show these cardiovascular risks can begin within just 30 days of starting the medication, even at low doses.

The People's Pharmacy

+4

Gastrointestinal Complications: Like other NSAIDs, it blocks protective prostaglandins in the stomach, which can lead to severe ulcers and a 4.5-fold higher risk of gastrointestinal bleeding compared to non-users.

Pulse Today

+1

Kidney and Liver Strain: It can reduce blood flow to the kidneys—causing acute kidney injury or worsening blood pressure—and has been linked to drug-induced liver damage.

Safer Alternatives Exist: Other nonselective NSAIDs like naproxen or low-dose ibuprofen generally offer a more favorable cardiovascular and safety profile for long-term use. Guidance from organizations like the GOV.UK Drug Safety Update explicitly contraindicates systemic diclofenac for patients with established ischemic heart disease, peripheral arterial disease, or heart failure.

nhs.uk

+1

Ok, whatever man.

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