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[–] 1 point 9 hours ago (1 child)

Except the drugs are originally always tested on men for efficacy, anyway so moot point.

https://medicine.yale.edu/news-article/a-drug-for-women-tested-on-men/

Yes you need to tell a doctor if you might have different organs than you apear to have, maybe there's an ectopic pregnancy, but medications, yeah not so much.

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  • [–] 4 points 8 hours ago

    I don't disagree with you - American pharmaceuticals in particular still seem weirdly gung-ho about excluding female participants from studies. Coming from Europe we routinely have to tell them they're not allowed to do that.

    ... but I think it's bad faith to say that bad study design makes my point moot, especially when it takes only a few seconds of Googling to find plenty of papers discussing sex-linked effects on drugs/medicinal products.

    Heck, here's a literature review of sex-linked effects on the pharmakinetics and pharmacodynamics of various drugs, which even acknowledges the bias towards males in various clinical trials you referred to.

    I don't think the paper mentions it, but I imagine throwing intersex people into the mix would render even more related differences. Which is why your assigned sex at birth matters medically, and I think it is dangerous to conflate it with gender identity (which again is your's to express as you please)

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