Depends on where you are and of it's safe. I live in a mostly safe city in the US, but the extremist propaganda from our federal government administration labeling us terrorists, sexual assaulters, and child abusers has made it risky everywhere.

However, I started using them pretty much as soon as I started presenting as femme, but I still years later and after having bottom surgery, tend to avoid using public facilities at all just in case. And only use it if it feels safe or is urgent and I have no choice. But I also do not use men's facilities at all as that would just feel way too wrong, so I just avoid any most times.

But that's me. I don't feel like I pass even with makeup, so it's relatively obvious I'm trans. I might feel more comfortable if I can ever get FFS, but there will always be stuff that gives it away. And considering the authoritarians are still assaulting cis-women who "look like a man" in this country, I'm not sure it will ever be totally safe.

So it's a risk game. If you feel safe, then do it.