Yes, I don't think the person on twitter understands or cares about that with respect to whether DID involves meds

I only read it as criticism of women for wearing makeup because its an extremely common line of joke where the butt of the joke is generally that women are dishonest about how they look because their makeup changes their appearance. Sometimes the negativity is explicit, sometimes it is implied. And that generally makes me uncomfortable with people joking about that kind of thing. Whereas glasses giving you a different appearance never gets wielded to attack women.

Were the elements that could be interpreted uncharitably not all combined here (joking about both makeup and also mental illness), and were the context an individual scale interaction rather than the interaction being turned into a meme for mass appeal at scale I might be inclined to interpret more charitably. But the former makes it feel more malicious and the later makes it feel more important that it not be harmful.