The meme implies she has multiple personalities. Having dissociative identity disorder (the condition that causes multiple personalities) is not a bad thing, but it is heavily stigmatized, and there is a very VERY long history of dismissing and degrading women on the basis that they're "less mentally stable", which mental health conditions can do, and carry the stigma of doing.

Hysteria was once a medical diagnosis given to women for "being to emotional and crazy", and the vibrator was invented by a doctor as a medical device intended as a treatment for hysteria. The entire origins of mental health as a field is rooted in "treating" women. And there is still today a patten of people dismissing women by calling them crazy (eg "my ex was crazy"), and a chronic problem in healthcare where women's health issues are not taken seriously and providers treat woman patients as if they're imagining things.

Its a very familiar narrative but its one that has been used to do a lot of harm to women, and so using it in a meme where you're also criticizing women for wearing makeup (a product of the way women are expected to compulsorily perform attractiveness) reads as sexist