Trans-folk are the only people I try to avoid using they to describe. I know it can cause discomfort, and potentially lead to others getting confused about pronouns if anyone listening doesn't know my grammatical quirks.
For everyone else I may use they for a variety of reasons. One of the most common: if a person's gender hasn't had clues about it in the conversation, I'm likely to just default to they. Like if I'm just calling my partner "my partner" rather than their name, I won't then specify gender with pronouns. Disclosing gender when it doesn't matter can feel weird.