There is good reason to limit off-target drug delivery, to minimize side effects in tissues that don't need exposure to the drug.

• Is the oral route more effective than topical?
• What are the systemic effects of the oral med?
• Was the study quoted in the article in any way funded by a pharmaceutical company that would be granted an exclusive license for a "new formulation," or is it trustworthy?

We actually do not know how medication works.

You'd be baffled knowing how we research new medications (it's randomly trying millions of different molecules).

One breakthrough where we know more is MRNA but that's just a small part.

And metabolism? We have a poor understanding of about 10-15%(we don't even know where it all happens or how much there is), the rest is unknown.

Do you? We have no idea how much of the medication works. We know it works in some parts better than others through observations and assumptions.

If we actually knew medicine, we tackle pain, injuries and other ailments through localised medical intervention, not taking a pill and hoping for the best.