science

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[–] Mantzy81@aussie.zone 42 points 6 months ago (6 children)

Tell us more about how you don't understand how medication works?

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[–] LetThereBeNick@lemmy.zip 1 point 6 months ago

There is good reason to limit off-target drug delivery, to minimize side effects in tissues that don't need exposure to the drug.

Is the oral route more effective than topical?
What are the systemic effects of the oral med?
Was the study quoted in the article in any way funded by a pharmaceutical company that would be granted an exclusive license for a "new formulation," or is it trustworthy?

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[–] Valmond@lemmy.dbzer0.com -3 points 6 months ago (2 children)

We actually do not know how medication works.

You'd be baffled knowing how we research new medications (it's randomly trying millions of different molecules).

One breakthrough where we know more is MRNA but that's just a small part.

And metabolism? We have a poor understanding of about 10-15%(we don't even know where it all happens or how much there is), the rest is unknown.

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[–] SaveTheTuaHawk@lemmy.ca 1 point 6 months ago (1 child)

Oh shut up. Every drug has a defined target.

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[–] Valmond@lemmy.dbzer0.com 1 point 6 months ago

Yes but we still start out with millions of molecules for each target. So shut up I guess?

Is everyone in this sub thread 11 years old?

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[–] patruelis@lemmy.world -2 points 6 months ago (1 child)

Do you? We have no idea how much of the medication works. We know it works in some parts better than others through observations and assumptions.

If we actually knew medicine, we tackle pain, injuries and other ailments through localised medical intervention, not taking a pill and hoping for the best.

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[–] Arklese1zure@lemmy.zip 1 point 6 months ago

Dude, you're literally describing pharmacology.

Localized effects have always been the goal, but actually making a drug that gets only to its intended destination, does a very specific thing, and doesn't escape to the rest of the body is very hard, very expensive, very painful, or a combination of the three.

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[–] fushuan@lemmy.blahaj.zone 18 points 6 months ago (8 children)

I meaaan, Paracetamol goes through the same process and it lowers headaches.

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[–] Mantzy81@aussie.zone 20 points 6 months ago* (last edited 6 months ago) (2 children)

Another example:

Ozempic gets injected into subcutaneous fat and works its way through the body, via the liver and heart, to alter the glp hormones in your pancreas and brain.

I'm sure we could think of lots of other examples where drugs are administered somewhere else to affect different areas.

OPs argument is as ignorant as flat-earth theorists.

Edit: and this shows this thread is a sausage-fest, as nobody mentioned either the pill or the morning-after pill which I'm sure most women would have probably said instantly.

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[–] patruelis@lemmy.world -2 points 6 months ago (1 child)

Whoever takes Ozempic is basically a lab rat at this stage. No short term issues have been observed but we don't know the long term effects.

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[–] Mantzy81@aussie.zone 1 point 6 months ago

All medication has the possibility of side effects.

In the 20 years GLP-1 medication has been used by type-2 diabetes patients (because that's who they were really for), there have been more positives than negatives. Simple as that. There are side effects but those are better than the well-documented side effects of type-2 (e.g. cardiovascular disease, kidneys, eyes and feet, including the possibility of amputation. And that's before we get into the social stigma of being morbidly obese, the mental health issues associated with that and the social isolation that often comes with it).bb

https://www.livescience.com/health/we-may-finally-know-how-tylenol-works-and-its-not-how-we-thought

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[–] patruelis@lemmy.world -1 points 6 months ago (1 child)

The. You just proved my point, we have no idea how paracetamol actually works, after 130years of study.

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[–] fushuan@lemmy.blahaj.zone 2 points 6 months ago

If we don't know how those processes work but we know the effect they cause, how can you so confidently say that the hair growth thing is BS? Knowing how it works is besides the point, if we know the effect it causes and it being ingested, how can you call bullshit to another thing having an effect in a different part of our body than where it's introduced?

I didn't prove your point and I'm sorry to learn you think I did.

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[–] Valmond@lemmy.dbzer0.com -2 points 6 months ago* (2 children)

And you shouldn't munch them too often because they do go through the liver etc.

OP has a point IMO.

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[–] fushuan@lemmy.blahaj.zone 2 points 6 months ago* (1 child)

What does that have to do with the fact that a pill being ingested has no direct relation with the place it has an effect on? That's the point I was trying to imply, thus countering the point OP was making.

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[–] Valmond@lemmy.dbzer0.com 1 point 6 months ago

IMO OP has a point as the delivery mechanism already exists (smearing it on the head) so making it take the longer way through our inner organs is, if not "bullshit" probably less good, as just smearing it has proven dangerous.

Maybe I just think nobody can be that stupid and believe eating a pill can't do something to the head.

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[–] SaveTheTuaHawk@lemmy.ca 36 points 6 months ago (1 child)

Oh look, an amateur pharmacologist.

This is why we grind aspirins into our forehead to relieve a headache.

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[–] village604@adultswim.fan 15 points 6 months ago

HEAD ON APPLY DIRECTLY TO THE FOREHEAD

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[–] iopq@lemmy.world 8 points 6 months ago

Yes, take a pill that goes to your stomach, absorbed by your intestines, into your bloodstream, liver, etc. to decrease your acne (isotretinoin)

... to stop asthma (salbutamol)

etc.

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[–] 4am@lemmy.zip 6 points 6 months ago

APLLY DIRECTLY TO YOUR FOREHEAD! APPLY DIRECTLY TO YOUR FOREHEAD!

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[–] magic_smoke@lemmy.blahaj.zone 3 points 6 months ago* (last edited 6 months ago)

You say that but oral/sublingual fin and estradoil worked much better than topical Finn/minoxidil alone.

That includes when I was still taking estradoil orally.

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[–] Whostosay@sh.itjust.works 1 point 6 months ago

It was originally for high blood pressure if I remember correctly. Side effect was unwanted hair growth. Very quickly became a topical for wanted hair growth.