As far as I know piracy has never been correlated with a loss of profit from a company, in fact I believe studies have shown piracy boosts visibility and actually slightly positively affects sales.

My understanding is that those who would pirate the game are unlikely to buy the game regardless and those who would buy the game are likely to follow the path of least resistance, eg buying the game from the store.

Also denuvo is very hacked and many of the games released with it now have day 1 cracks.