Most of these are just gimmick characters that will have one fun interaction with the group and then become useless. They can be used for one-shots, but not full campaigns.
Like the dragonborn one, after the initial interaction where they explain the skin condition. Most players will just go "okay" and move on.
Except for the sentient hat one. That has a mystery attached and you can keep changing the mannequin throughout. Maybe it also works on a mop or barrel.