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Dunno if it would meet your needs, but I've been using Input Remapper for binding macros to various key presses and mouse buttons under Wayland. It does prompt for root access, but it's a GUI. It supports any input method, as far as I can tell. It even supports my tablet.
I use it to bind stuff like hold(key(BTN_LEFT).wait(100)) to some button to repeatedly left click while I'm holding that button down.
Does Actiona suit your needs?
It's not GUI, but I want to mention another alternative, as people mention commandline applications here too: kdotool, works under KDE Wayland without with normal user rights (no root). They still work on a few features, but it can do lot of windowing stuff already. A good addition to ydotool.
Maybe autokey? https://github.com/autokey/autokey
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