Background - Vegetarian diets might influence cancer risk.

Methods - We studied 1,645,555 meat eaters, 57,016 poultry eaters, 42,910 pescatarians, 63,147 vegetarians and 8849 vegans in 9 cohorts (UK, US, Taiwan, India). After a median 16 years follow-up, incident cancers were: 4504 mouth and pharynx, 1308 oesophagus (squamous cell), 2105 oesophagus (adenocarcinoma), 3578 stomach, 30,528 colorectum, 2970 liver, 8030 pancreas, 3077 lung (never smokers), 61,368 breast, 11,220 endometrium, 8076 ovary, 45,946 prostate, 7193 kidney, 6869 bladder, 11,651 non-Hodgkin lymphoma, 4658 multiple myeloma and 7306 leukaemia. Multivariable Cox regression was used to estimate cohort-specific hazard ratios (HRs) and 95% confidence intervals (CIs), and the results were combined using meta-analysis.

Results - Compared to meat eaters, poultry eaters had lower risk of prostate cancer (0.93, 0.88–0.98), pescatarians had lower risks of colorectal (0.85, 0.77–0.93), breast (0.93, 0.88–0.98) and kidney cancer (0.73, 0.58–0.93), vegetarians had lower risks of cancers of the pancreas (0.79, 0.65–0.97), breast (0.91, 0.86–0.97), prostate (0.88, 0.79–0.97), kidney (0.72, 0.57–0.92) and multiple myeloma (0.69, 0.51–0.93) but higher risk of squamous cell carcinoma of the oesophagus (1.93, 1.30–2.87), and vegans had higher risk of colorectal cancer (1.40, 1.12–1.75). Conclusions

Vegetarian diets might influence risk for several cancers. The generalisability should be considered cautiously.

Full Paper - https://doi.org/10.1038/s41416-025-03327-4

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[–] [S] 6 points 2 days ago* (last edited 2 days ago) (6 children)

Observational data, FFQs, epidemiology cannot establish causation only correlation, it's hypothesis generating.

They corrected for confounders, which assumes they can establish a causal correction factor (pre-supposing the solution to the research question) - Age, sex, geographic region, recruitment method, education, living with a partner, ethnicity, height, smoking status, smoking intensity, tobacco chewing (CARRS-1 only), alcohol intake, physical activity, BMI, diabetes history, parity, hormone replacement therapy use, age at menarche (female-specific cancers), age at first birth (female-specific cancers), menopausal status (female-specific cancers), oral contraceptive use (female-specific cancers), PSA screening history (prostate cancer).

However, with all of that, they did not control for carbohydrates or underlying metabolism.

They included the 7da health studies that define vegetarian as meat at most once per week, and vegan as at most once per month... but didn't mention that in their definition section.

They exclude datasets because of low adherence to a vegetarian diet, then at the end applaud the vegetarians for having a high adherence rate. You can't do both in good faith.

They keep confusing causal statements in the paper, where they also caution against making causal conclusions... they keep using risk, when they need to say association.

It's a interesting dataset, i would recommend only looking at the hr forest plots and not the opinion around it.

If red meat gives you colon cancer, why do vegans have a higher association when compared to omnivores?

They spend alot of time speculating about that, calcium, micronutrients, etc, etc, they never mention sugar, and carbs as possible factors.

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  • [–] 3 points 1 day ago* (last edited 1 day ago) (4 children)

    If red meat gives you colon cancer, why do vegans have a higher association when compared to omnivores?

    Not sure about the red meat. The paper talks about vegans eating insufficient calcium. If you add dairy to their diet, the risk is reduced.

    Edit: Remember most of these people are probably on a particular diet for cultural or economic reasons and vegan for moral reasons.

    If they optimized their diet and lifestyle for health, I feel the outcomes would be vastly different.

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  • [–] [S] 3 points 1 day ago* (1 child)

    The paper talks about vegans eating insufficient calcium.

    They speculate with their opinions, but that doesn't address the schism in the data.

    If you add dairy to their diet, the risk is reduced.

    You are making causal statement from observational data. This data, and especially the authors opinions, don't inform us on cause and effect. This is not the right type of study to give you any advice on your diet.

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  • [–] 2 points 1 day ago

    I agree that the causal connection to calcium or other micronutrients needs demonstration.

    I see it as weak but best available evidence so far. So we can use such data / speculations to improve your lifestyle or reject them. Completely up to you.

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  • [–] 4 points 18 hours ago (2 children)

    Certainly it couldn't be pesticides causing this result. /s

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  • [–] [S] 3 points 18 hours ago (1 child)

    That is a good thought; this dataset doesn't really control for pesticides.

    The different food groups they identify are all plant based, even the meat eaters are standard meat eaters so about 70% of their food is plant based already - there is no zero carb arm.

    If pesticides were a problem here, even the meat eaters may be impacted.

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  • [–] 3 points 10 hours ago

    I think yes, the meat eaters should be. It's also possible that direct exposure has significant impact... Also, are the animals eating pesticide laced crops like the vegans, or hay, or other grass?

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  • [–] 3 points 1 day ago

    Epidemiology fight! Everyone loses, all this is is a misallocation of resources. Hopelessly confounded.

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  • [–] 2 points 8 hours ago (1 child)

    So meat eating lead the pack in cancer cases over all other diets, even adjusted proportionally, except for a couple specific types? I guess that lines up with most other research. I'd be interested to know what causes the difference, particularly between vegetarian and vegan which I assumed would be pretty similar.

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  • [–] [S] 2 points 8 hours ago

    So meat eating lead the pack in cancer cases over all other diets, even adjusted proportionally, except for a couple specific types?

    The study makes no statements along those lines, it does not provide hazard ratios of overall cancer incidence by diet.

    I'd be interested to know what causes the difference, particularly between vegetarian and vegan which I assumed would be pretty similar.

    Access to animal based foods, carbohydrate load, fructose load, seed oils, calcium, B12 can all be elements for the difference

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  • [–] [M] 1 point 2 days ago* (last edited 1 day ago) (1 child)

    For those wondering why this is appropriate for a carnivore community:

    Seeing high cancer rates in vegans tells us either meat is protective or plants are harmful, each are good reasons to eat meat

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