Her experience, while not the norm, is far from unusual, experts say.

Applegate disclosed the revelation on an episode of her podcast with Jamie Lynn Sigler, MeSsy, which centers on their lives with MS. (Sigler disclosed that she has relapsing-remitting multiple sclerosis, or RRMS, in 2016.) “In January of 2021, I had numbness in my toes, and that numbness grew to all of my legs,” Applegate recalled on the podcast. “And then the pain started.”

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[–] 58 points 3 weeks ago (9 children)

Applegate said that while everyone in her life was relieved, her reaction to the news was that she was "not happy at all," noting, "You don't get misdiagnosed and then all of a sudden I'm better. I haven't gotten better, Jamie. If anything, I've gotten worse in some ways. So I'm back at square one, that I don't know what's going on with me."

From the USA Today article. I gather this is really common reaction for people with chronic or progressive illnesses, when they find out they don't have the terrible thing they were misdiagnosed with. Like, everyone else is all "yay! no MS!" and the person who is still experiencing the symptoms that led to the misdiagnosis is like "ok, but I'm not suddenly healthy, and now I have to start over." You can at least plan things when you know what you have.

Her symptoms sound really bad, too, and if there's a treatment for what she does have, she's not getting it.

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  • [–] 10 points 2 weeks ago

    Yeah, that's the reason I was actually excited to be diagnosed with celiac even though I hate nothing more than having it. It sucks going like 15 years with severe issues but nobody being able to figure out what's causing it

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  • [–] 2 points 2 weeks ago (7 children)

    There is no treatment for any neurodegenerative disease. There is no funding in the US for any neurodegenerative disease as of 2025.

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  • [–] 9 points 2 weeks ago (3 children)

    There’s no treatment that restores function, but there are numerous treatments that slow or even stop disease progression with MS, which are much better than what was an available 15-20 years ago. A diagnosis at least gives hope of some ability to mitigate worsening symptoms.

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  • [–] 2 points 2 weeks ago

    Yeah, I know two people with MS, one has been diagnosed for a decade and a half and with medication she's doing okay, one was diagnosed earlier this year, but is already receiving treatment intended to slow/stop progression.

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  • [–] 0 points 2 weeks ago (1 child)

    There is no treatment that stops MS.

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  • Not that reliably stops it for all patients or for unlimited time, but the current mainstream treatments are way more effective than what was generally available 15-20 years ago. I’ve been on my current twice-annual infusion for more than 8 years now with no relapses or new lesions. That is a halted disease progression, and though it may not last indefinitely, for the time being, for me, it is effectively stopped, and the same is true for countless others.

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  • [–] 2 points 2 weeks ago (1 child)

    There is no treatment for any neurodegenerative disease

    I don't know how technically specific you're trying to be here, but there are definitely treatments for some diseases that have major neurodegenerative effects, such as pernicious anemia.

    For that one, the treatment is amazingly cheap (B12 injections), but most US doctors are decades behind in understanding and applying it.

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  • [–] 31 points 3 weeks ago (5 children)

    After rounds of tests for a variety of conditions, her doctor found “almost 40” lesions on her brain and diagnosed her with MS, she said.

    Now, five years later, Applegate said that, after analyzing brain scans with a “new technology,” her doctor told her she doesn’t have MS.

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  • [–] 3 points 2 weeks ago

    Estimates vary, but a recent meta-analysis found that around 15 percent of MS cases across studies were misdiagnoses.

    Diagnostic tools are getting better. In 2025 the International Advisory Committee on Clinical Trials in Multiple Sclerosis updated its guidelines on how to diagnose MS to reflect recent advancements....

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  • [–] -2 points 2 weeks ago (2 children)

    This whole story makes no sense.

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  • [–] 5 points 2 weeks ago
    • Patient diagnosed ~5 years ago.
    • Disease presents similarly to several neurological disorders and has a known misdiagnosis rate between 5 and 20 percent (15% for the study mentioned in the article).
    • Disease has seen developments in imaging and interpretation since original diagnosis.
    • Prominent person announces they were misdiagnosed, but the symptoms persist.
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  • [–] 0 points 2 weeks ago (3 children)
  • [–] 2 points 2 weeks ago (2 children)

    One of the leads of "Dead To Me" (among other things).

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