I'm sure. Polish won't fix the pleather, it'll create a nice-looking polished layer over the pleather if you remove the flakes first. I did it with my boots, removed all the flaking and damaged veneer I could and then polished them like normal multiple times.
There's no repairing damaged pleather that I'm aware of, only replacement, but if they want to keep using the shoes, then layers of polish will extend their life, especially cosmetically.
