Yeah, if I were to attempt these, I'd precook the ground beef so I could drain it appropriately, then try to assemble and finish the pepperoni and cheese under like a low broil. But I'd cook the beef itself relatively unseasoned in the hopes that either mixing it with pizza sauce or layering pizza sauce between the beef and cheese would tie everything together flavor-wise.

I'd also skip the pepperoni entirely because it gives me nightmarish heartburn, but that's neither here nor there.