Oh no Chicago is massive. Has Willis/Sears tower which was once the tallest in the world. Is a major financial hub for thr stock exchange. Has a massive arts and good culture. Has O'Hara International Airport with flights all over the world. Many films and TV shows at there or in its suburbs.
It doesn't have as many familiar landmarks as San Fran, maybe. And San Fran is has gotten more important with the rise of Silicon Valley which shares the bay area. But Chicago is a big deal in the US, for sure.
Minneapolis really only matters within the midwest.