I tried thinking of what could actually truly not work as an animated film/show, and all I could think of was reality TV. No one wants to watch the Bachelor or Survivor as an animated adaptation. The whole point of those types of shows is to see actual people doing things for real. Even documentaries include reenactments, as those are more focused on conveying information, so a fully animated documentary could be fine as long as the audio track was accurate. But reality TV is about depicting reality. Animating a reality show would involve altering that reality in such a way that it is effectively not reality TV anymore.