It will if it's inside the engine, as in inside the crankcase where oil goes. Your fuel filter will block any sediment, and there isn't a ton that dissolves in gas. If the only thing you have available is the gas tank you want to add an oxidizer. Bleach in a gas tank will fuck an engine up, as will a few non petroleum fuels. Diesel will stall a gas engine, sand and sugar do nothing, but bleach will internally rust every bit of iron in the fuel rail and inside the cylinders.