The show stopers are some banking apps that don't work and tap to pay
If that's not an issue for you, then I've had zero problems running GOS. You'll spend the first week figuring out using different profiles, the cleaner interface, installing things that you actually want. But after that you won't even notice the difference.
I use Android auto, I have Google installed in a profile for it, everything else is clean without Google, everything works fine.