uv mostly gets rid of the "venv activation" thing (mostly bc you can still use it if you really want, but you don't need to), you can do uv run main.py and it'll just work, no need to even install packages explicitly, it'll also do that for you and make sure your uv.lock is in sync with your environment.

it's the most hassle-free experience I've had with python, by a long shot.