[–] 5 points 2 days ago

I'm a biologist so I see experiments and results from gene editing somewhat often in presentations and papers. It's not quite the hot thing that it was 10 years ago, but it's still very relevant.

Most discoveries that come out of this sort of work are quite niche, and often discovered using non-human models. Some of that may only now be getting into human models, but I'm not aware of any (I'm not "that" kind of biologist).

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  • [–] 20 points 4 weeks ago (3 children)

    Following this metaphor, I see it as: US Left: car's in neutral on a steep incline, foot is off the brake and they aren't sure if they're moving backwards or everyone outside is moving forward. Regardless they think they're doing a great job.

    Center: same as above but they're complaining that everyone outside is going too fast that they may have even gone past their destination.

    Right: same car, same place, but the car's in reverse and the foot is on full throttle. The center is still complaining about the speed but they're enjoying the view. The US Left is now fully aware of the backwards movement but it doesn't want to take the seatbelt off for the sake of self preservation at the cost of everyone else outside. The rest of the world is either steering clear or has been reversed in to like in one of rear-end insurance scams.

    Driver changes every 4 years.

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  • [–] 5 points 3 months ago

    In terms of large, North American fast food chains, I like A&W, Carl's Jr/Hardy's, and Jack in the Box. In terms of smaller, regional chains, I think In-N-Out is leaps and bounds the best (though What-A-Burger is also really good). Outside of North America, I'm a pretty big fan of Mos Burger from Japan. JollyBee from the Philippines is also pretty great, but mostly because they serve spaghetti and I find that amusing.

    I think Shake Shack is overrated but worth trying. FiveGuys is meh.

    I also firmly believe that smaller burger chains like In-N-Out, Shake Shack, and What-A-Burger are probably more or less equal in terms of quality and what determines which you think is best is where you grew up.

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  • [–] 5 points 3 months ago

    I, for one, congratulate the senator from Kentucky on ascending from "Mitch McConnell Turtle Jowel" to "Mitch McConnell Meat Muppet". Truly, we've come leaps and bounds from the days of yore and consumption, to the tomorrow of "human centipede" model of economics and explosive diarrhea.

    What time to be alive.

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  • [–] 2 points 3 months ago

    Depends on the question. In general, I ask my partner and she often doesn't know, so we quickly browse both reddit and quora for similar questions, laugh at the generally insane/inane responses that users often give, forget what we were doing and move on to something else.

    Otherwise, I go for stack exchange and hope for the best.

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  • [–] 3 points 3 months ago

    https://onlinelibrary.wiley.com/doi/abs/10.1002/jez.b.22690

    See above for a possible explanation for the evolution of female orgasms. Tl;dr: in humans, it may be a trait derived originally from induced ovulation in more evolutionarily distant ancestors and changed to become what it is in humans over evolutionary time.

    In a general evolutionary biology sense, "why" questions are a lot harder to answer than "how" questions. Many answers to "why" that are often given as "that makes sense" are often untested "just so" explanations.

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  • [–] 3 points 3 months ago

    It might, but exceedingly rarely. Albinism and melanism occurs in many taxa including species in the genus Panthera (which include lions and tigers). These are rare traits in general because they are selected against for one reason or another and don't proliferate in the wild.

    Another possibility is that these phenotypes are linked to genes that have other downstream developmental effects that lead to non-viable fetuses.

    Another fun one (possibly) is that some of these coat traits are controlled partially by the environment/the animal's spatial relationship with the environment. Siamese cats have the characteristic darker coat colors on their extremities (ears, paws, tails, snout, this is called acromelanism) because the melanism is controlled by lower temperature. If an animal never experiences a low temperature, that phenotype might never be expressed.

    These are all possibilities. I'm a biologist but I don't study felids (cats and big cats).

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