I was following along until the bf stuff. What helps me is communicate up front, do I want to be heard, helped, or hugged. Three Horizons framework. Go easy on bf, it’s easy to misunderstand especially over the phone.
So explain why violent crimes plummeted when PlayStation and GTA came out. It’s lead poisoning from leaded gasoline. We cut that out and it’s been trending down. If violent video games have any impact, it’s likely to reduce physical violence instead of increase it.
So not efficacy
Only if psychological effects could impact the result. That doesn’t apply with vaccines, does it?
I hate to say it, but this one I agree with RFK Jr on. You have to have a control group. If it’s ethically wrong to not treat with the standard of care then make the placebo group opt-in to placebo so they know they are not getting the current standard of care.
You can still do the compare vs current standard of care, but also need the placebo. Also diseases can evolve so re-comparing to baseline should be a must to make sure the current standard is actually helping like we think it does.