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Stanford scientists regrow lost cartilage and reverse arthritis in major breakthrough (www.sciencedaily.com)
submitted 4 months ago by to c/technology@lemmy.world
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[–] 75 points 4 months ago (5 children)

Ready for someone to tell me why this unfortunately won't work / become mainstream

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  • [–] 43 points 4 months ago (3 children)

    Money, usually. Or cancer. God i sound depressing 😄

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  • [–] 30 points 4 months ago

    Well, this same drug (working name MF-300) is a PDGH-15 inhibitor and has already been through phase 1 human trials for a separate condition.

    Because PDGH-15 also causes age related muscle weakness.

    Now, PDGH-15 also plays a role in cancer prevention, and there may be a few other less obvious functions.

    I don't know if the results of the phase 1 trials have been published yet, but it's been a while since I checked.

    I've been hearing about MF-300 for a little under a year, and with these same claims about restoring cartilage.

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    • [–] 123 points 4 months ago (23 children)

    This and then the new about regrowing teeth. Its a very exciting time in medicine.

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  • [+] -36 points 4 months ago (22 children)

    If you think anyone but the elite will be able to afford or procure these procedures, you're incredibly optimistic.

    As soon as it gets approved, some shitty corporation will purchase the patent and lock it behind a paywall for 80+ year old geriatrics with zero fucks given towards people who actually deserve or need it.

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  • [–] 28 points 4 months ago (5 children)

    This drug can be delivered via pill. It has a range of effects in reversing age related damage.

    I'm not sure if it will be kept to the rich, or given out widely to justify the removal of social security, or at least jacking up the retirement age.

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  • [–] 10 points 4 months ago

    Maybe, but if PGE2 signaling is disrupted in non-cartilage tissues, it could promote abnormal growth or inflammation. For example, PGE2 has complex roles in cancer and fibrosis. And if the drug isn’t perfectly specific, it might inhibit other enzymes or pathways. This is because 15-PGDH is active in other tissues (e.g., liver, muscle, bone). Inhibiting it systemically might affect these tissues, though the study suggests localized joint injection could minimize this I suppose...

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  • [–] 0 points 4 months ago (2 children)

    If the worker-slaves live longer, you don't have to indoctrinate & capture new ones quite as often!

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  • [–] 13 points 4 months ago (1 child)

    I'd like my partners knees to work again so they can do the things they like as they age, like riding bikes or hiking.

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  • [–] 15 points 4 months ago (12 children)

    Lol Yankee problems

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  • [–] -2 points 4 months ago (11 children)

    I'm not a Yankee, but thanks for assuming

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  • [–] 2 points 4 months ago* (last edited 4 months ago) (10 children)

    You're an American, that's what Yankee means to everybody outside the states.

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  • [+] -7 points 4 months ago (8 children)

    Are you seriously also down here saying racist shit to a Native American so that you can roleplay some flex on what you thought was just some poor USAmerican who couldn't afford healthcare? Your good guy scenario was dunking on a poor person in an authoritarian state?

    Europeans are seriously the most bloodthirsty fucks I'll see online, and they're predictably the most smug about it too.

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  • [–] 8 points 4 months ago* (7 children)

    I have no idea what you're trying to say. Are you saying he's NOT an American because he's indigenous? And wtf is racist? At least now I know what his comment means. You people think everybody knows the same things you do.

    (I'm Asian BTW, but yeah go on)

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  • [–] -2 points 4 months ago (4 children)

    "It isn't racist to call a Native American a 'yank' because I'm ignorant about racism." You're telling me that you moderate a Norwegian community, talk a shit ton about Euro nations, but you think it doesn't make you look like a racist asshole to not know what is racist about trying to dunk on an indigenous person (who, again, you thought was just some other poor person) by calling them a term that identifies them with the occupying settler state that has committed genocide against their people.

    Yeah dude, totally not a bloodthirsty chud.

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  • [–] 4 points 4 months ago (3 children)

    "It isn't racist to call a Native American a 'yank' because I'm ignorant about racism."

    Courtesy of Wikipedia.

    Outside the United States, Yank is used informally to refer to a person or thing from the US. It has been especially popular in the United Kingdom, Ireland, South Africa, Australia, and New Zealand where it may be used variously, either with an uncomplimentary overtone, endearingly, or cordially.[4]

    Again with the Americentrism defaultism. You think that just because some people in your country use it as an insult or whatever, it must be true worldwide.

    Would you like to explain how I was 'dunking' on an indigenous person when my statement was nothing more than explaining what Yankee means to the average non-American?

    identifies them with the occupying settler state that has committed genocide against their people.

    Dude, that's your internal history. What makes you think any non American gives a shit about it?

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  • [+] 0 points 4 months ago (3 children)
    [removed by mod]
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  • [–] 4 points 4 months ago (2 children)

    I'll be frank, I still have no freaking idea what your problem is.

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    • [–] 42 points 4 months ago (1 child)

    I want this so bad, I have lost all cartilage in my wrists and I don't want to get them fused.

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    • [–] 31 points 4 months ago (3 children)

    I would like to order one new left knee cartilage please!

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  • [–] 11 points 4 months ago (2 children)

    Just take some from someone. Jeez, the learned helplessness of some people...

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    • [–] 52 points 4 months ago (40 children)

    Good. Biological aging is nothing more than a series of processes, not an inherent property of atoms, and it's time we start getting serious about anti-aging and life extension.

    But probably not, seeing what the world is like.

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  • [–] 40 points 4 months ago (22 children)

    Its mostly billionaires who will be able to benefit from life extension... do you really want a world where trump, musk, and all their silicon valley friends rule the world until they turn 300 years old?

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  • [–] 6 points 4 months ago (2 children)

    Why do you think that? We already benefit from life extension. And why only 300?

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  • [–] 3 points 4 months ago (1 child)

    "I plan to live forever, of course, but barring that I'd settle for a couple thousand years. Even five hundred would be pretty nice."

    CEO Nwabudike Morgan, "Sid Meier's Alpha Centauri" (1999)

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  • [–] 1 point 4 months ago (12 children)

    No worries about that, there is no changing the maximum age seemingly, not unless you genetically engineered babies with tech we don't have yet.

    Everyone is born with stem cells that carry so many copies of cells that are preprogrammed to die after a point to then be replaced by those stem cells. No drug can make more copies after the fact.

    Then of course the dna gets denatured just by radiation and pollution and time.

    Neither of these will or can be solved after someone is born. They can extend the average lifespan of a group, but they can't exceed the maximum, which has remained constant throughout human history even as the average has changed drastically.

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  • [–] 3 points 4 months ago (3 children)

    All of those things seem to be related to information processing, not any inherent property of atoms.

    "Then of course the dna gets denatured just by radiation and pollution and time."

    Pretty sure "dna" isn't just present in one cell in the body.

    Also, how can two thirty year olds make a zero year old baby?

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  • [–] 1 point 4 months ago (2 children)

    Have you read anything about this before espousing your grand pronouncements here?

    Seriously, like, you are so far in left field here, I can't even respond.

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  • [–] 1 point 4 months ago (1 child)

    https://vadim.oversigma.com/MAS862/Project.html

    But lay on MacDuff, pour your great knowledge upon me. Tell me how a carbon atom knows it's in a thirty year old body or 95 year old?

    "Also, how can two thirty year olds make a zero year old baby?"

    Surely you can respond to this puzzler? Even if I'm in the left field of the Andromeda Galaxy?

    Explain away, professor!

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  • [–] 1 point 4 months ago (1 child)

    I thought the central problem was telemore degeneration, not anything to do with stem cells per se.

    Happy to be corrected if wrong; I never worked anywhere near this category in my very long ago now pharma/biotech phase.

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  • [–] 2 points 4 months ago

    That is part of it, which is what I alluded to in the degeneration of the dna. The stem cell thing too though. Our bodies aren't programmed to live beyond a certain point. We learned about this in a Nature of Disease course at University.

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  • [–] 1 point 4 months ago (5 children)

    What's the maximum? About 120?

    Imagine having 100 or more healthy years. That seems like sci-fi, but may be possible one day still.

    It will also mean working until you're 100 before the national pension kicks in unfortunately lol

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  • [–] 1 point 4 months ago (3 children)

    National pension

    Ngl, you had me in the first half...

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  • [–] 2 points 4 months ago (2 children)

    They nearly had me in the first quarter, but now I no longer believe I'll ever see it. Not enough young people are born. My generation is enough to support the current old people, but there won't be enough people to support my generation.

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  • [–] 1 point 4 months ago (1 child)

    Are there enough people at the current system where the top 1% get 99% of the resources? ¯\_(ツ)_/¯

    But there will 100% be enough people to keep the basics going

    We are thousands of times more efficient than we were a couple hundred years ago.

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  • [–] 1 point 4 months ago

    The top 1% don't get 99% of the resources, they get 99% of imaginary wealth. It can't be sold off en masse.

    Ergo, we don't have a magical extra 100x increase in actual goods and other physical resources per person coming if we just kill the 1%. Things could be distributed much more fairly for sure, but it's not as simple as "these few people own everything so if they're gone, everyone else is a millionaire".

    Anyway, much of the "basics" is going to be in person care work with an aging society. We haven't handed that off to AI yet, nor medicine, but once that's happened then yes we can actually handle social safety nets in an aging society. Right now the solution they're going for is a constant increase in retirement age to keep the tax revenue high enough to pay for retired people's needs.

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  • [–] 1 point 4 months ago

    Around 120 is maximum yes. I think some french woman might have gotten near 130 but I forget.

    Unless you believe the bible, in which case hundreds and hundreds of years. And woman was made from man's rib. Makes sense.

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  • [–] 6 points 4 months ago (6 children)

    I didn't realize people weren't being serious about it this whole time. The tens of millions of dollars of research grants seemed pretty serious.

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  • [–] -1 points 4 months ago (5 children)

    LOL that pays for a focus group for branding. You can't be serious.

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  • [–] -1 points 4 months ago (4 children)

    You're telling me you're a "huge nerd," but think medical research is done by companies and involves focus groups? Like, it's a Marvel or something?

    Jfc. If 90 million dollars isn't anything to you, howbout you give yours away then bud.

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  • [–] 1 point 4 months ago (3 children)

    Yes, medicine is marketed. Are you for real? Like, is there still amniotic fluid behind your ears? Great Hatching Day fellow creature! Welcome to Earth!

    My joke was that tens of millions of dollars to research aging barely covers the test tubes. JFC.

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  • [–] -1 points 4 months ago (2 children)

    Bud, they don't market for a treatment before there's even research conducted. How the fuck are you acting like you think giant research grants are not effort? Give me ten million dollars if it isn't much then.

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  • [–] 0 points 4 months ago (1 child)

    Sigh. What kind of absurd logic are you using? Do you not get sarcasm? I'm saying in the scheme of things, ten million dollars is nothing. The fact I don't have ten millions dollars is irrelevant and your type of argument is at the level of an eight year old's.

    We spend more than that developing idiotic video games that mean nothing.

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  • [–] 0 points 4 months ago

    "Le Sigh. You are but a juvenile child, and I the calm and logical adult. The arguments I make are simply too complex for such an underdeveloped mind; my explanations would only fall on deaf ears. Even the machinations of my coy wordplay is lost on you, clearly, for you could not even decipher the hidden meaning behind my deceptively foolish appraisal of this society's motivations. My account is of the sheer scale of human productivity, a folley by which your feeble little brain could not even begin to comprehend."

    Dude, you're cringe. People have literally been obsessed with medicalizing anti-aging since before the Renaissance. You think we're only just now, in 2026, taking arthritis seriously? C'mon. You said something dumb and you're too much of an internet trilby enthusiast to even take a second and consider what it means that thousands of people are applying for, acquiring, and expending massive amounts of grant funding toward this endeavour and have been doing so for decades.

    Not gonna be engaging with this anymore, only made this comment because of how you characterized yourself in this response.

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  • [–] 2 points 4 months ago (2 children)

    People have been seeking life extension for all of recorded history.

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  • [–] 1 point 4 months ago (1 child)

    And we've achieved some of it, or are you telling me giving birth in hospitals, vaccines, and working in air conditioned offices doesn't extend life somewhat? People were also seeking powered flight for all of recorded history.

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  • [–] 2 points 4 months ago*

    Most people are referring to the inherent genetic features of our biology that causes aging. Because we didn't even know such a features existed until relatively recently. Before that was discovered we thought aging was just caused by all the crap life throws as us and it looked like all we had to do was just keep improving things to functionally have humans who live "forever. "So as far what I've heard from scientists, we're at wall in this area because we still have no idea what the vast majority of the genome even does.

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  • [–] 1 point 4 months ago (2 children)

    Is it though? The only time progress happens is when people die.

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    • [–] 25 points 4 months ago

    I'm glad to hear that stuff like this is still going on. Nice!

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    [–] 96 points 4 months ago (18 children)

    Probably worth adding "in mice" to the title

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  • [–] 41 points 4 months ago (11 children)

    Mice are really living in a golden age. They have never been so healthy.

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  • [–] 22 points 4 months ago* (5 children)

    The only downside is the never ending genocide at the hands of scientists

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  • [–] 2 points 4 months ago (2 children)

    Is it still genocide if the ones killing are also reproducing them?

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  • [–] 2 points 4 months ago (1 child)

    It's kinda worse. Imagine if aliens came here and not just killed us all, but bred us only to be experimented on and then horribly dying with less than 1% living a bit longer and maybe experience some odd things the others didn't. Like a factory where the first machine is making us have children before we get killed then doing the same for our kids ad infinitum.5

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  • [–] 27 points 4 months ago (2 children)

    And human tissues, and it's been shown to be safe in phase I trials.

    So saying "in mice" undersells where they are at.

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