I looked briefly at Glock slides a while back, 17-4 stainless appears to be a common choice. As long as you can drill the firing pin hole straight (a challenge but not impossible) I don’t see why not.

Shoot me a model though and I’ll take a closer look.

Edit: already at the desk so I pulled up unseenkiller’s reference files.

The inward face of the spring guide is milled flat, but you could probably get away with adding some material to the front of the slide and just using a long 110° drill and make it a bit deeper. The hole is very shallow so if you drill the small diameter from the front, your long drill shouldn’t walk if it can follow that hole from the other side. That’s how I’m doing this slide.

The striker channel you will definitely need at least a drill press with DRO to make sure your depths are good, and you may have to figure out how to compromise to use the chamfered faces your drills will leave rather than the flat faces shown in the reference file. Not sure if that’s a big deal for the design function or not.

Otherwise, if I can make this LCP slide, I don’t see anything that would hold you back.

Keep in mind that any 90° internal corners you see at the breech face will have to be hand filed.