(TBoI:Re = the Binding of Isaac Rebirth)

For the curious, the combo is Chaos (the smile) + Holy Light (the eyes).

A screenshot of the Binding of Isaac Rebirth showing the protagonist, Samson in this case, making a smug face with his eyes shining in a blue light.
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(TBoI:Re = the Binding of Isaac Rebirth)

For the curious, the combo is Chaos (the smile) + Holy Light (the eyes).

A screenshot of The Binding of Isaac Rebirth, showing the protagonist, Samson in this case, with a smug face and shining blue eyes.