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[–] 38 points 10 months ago (4 children)

That's a really good way to waste a lot of Adderall.

Bioavailability of Adderall when introduced into the lungs is like <10%.

Gastric absorbtion is 90%. Doesn't take a genius to know that maybe you shouldn't smoke something that doesn't get absorbed well that way.

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  • [–] 11 points 10 months ago (1 child)

    So boofing it is the way to go?

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  • [–] 10 points 10 months ago

    Uh

    No. It's actually absorbed by the stomach, and requires the gastric acid to do it. Stomach acid is usually rendered neutral in the large intestine. I would suspect it would be the same as inhaling it, but I have no clue.

    Plus, while Adderall would damage your lungs, I'm pretty sure boofing it is a good way to lose your lower intestines.

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  • [–] 60 points 10 months ago

    It does go crazy though

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  • [–] 28 points 10 months ago

    Regular reminder to not do meth, kids. Not even once.

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  • [–] 27 points 10 months ago (1 child)

    I'll die of excitement while mowing the neighbour's lawn with scissors.

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  • [–] 18 points 10 months ago (7 children)

    Caffeine + sertraline + thc = maximum productivity

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  • [–] 13 points 10 months ago (5 children)

    Imagine a person taking so many drugs that you end up anxious, tired, and depressed like they were before taking the drugs.

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  • [–] 4 points 10 months ago

    Man Sertraline used to fuck me up pretty bad. Like crying every day and not doing anything else. My doctor still insisted on dosing me up to 150mg. Quitting it was awful too, I was nauseous for a week straight.
    Nowadays I'm much better on Adderall and a Beta Blocker to keep my heart rate in check

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  • [–] 20 points 10 months ago (2 children)

    So while Adderall is an Amphetamine, more specifically it's multiple amphetamine salts packed into one container, and in high doses can cause psychosis, the major difference is that Methamphetamine's Methyl chain at the attachment point makes it heavily lipophilic causing it to dissolve into body fats, causing its tooth-decay side effect and also making it easier to pass through the blood-brain barrier.

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  • [–] 14 points 10 months ago (1 child)

    It’s slightly more lipophilic, not heavily so. The main draw of meth from a pharmacodynamic perspective is that it slows enzymatic degradation (you’re high longer). On a mg for mg basis dextroamphetamine is actually stronger than meth.

    Tooth decay is caused by dry mouth and poor hygiene. The added methyl group doesn’t affect this aspect.

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  • [–] 0 points 10 months ago

    I'm no expert on illicit substances, but teeth are a bone matrix FILLED with lipids, that's theorized to be why certain bacteria target and eat away at the teeth in the first place while other common bacteria simply produce acids which demineralize teeth as a side effect, and the Methyl compounds will bond directly to the teeth creating a dental biofilm in this case accelerating decay, this property is used by some dental coatings in order to apply permanent ceramic fixtures to teeth with methyl methacrylate and the property is also the major cause of stains on teeth caused by smoking.

    Adderall also causes dry mouth but is not associated with the same level or severity of tooth decay.

    This would probably actually make for a great area of research on if different "types" of meth like methoxy, methyl, halogen, or sulfur have different severities on dental health and if there is not then it would immediately prove me wrong, but I personally could not find any such study.

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  • [–] 2 points 10 months ago

    crazy how the "adderall is meth" stigma still exists

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