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GLP-1 may slow biological aging (www.universityofcalifornia.edu)
submitted 3 weeks ago by [B] to c/hackernews@lemmy.bestiver.se
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[–] 7 points 3 weeks ago (2 children)

May also means may not

We can rewrite the title as

Glp1s may not slow biological aging

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  • [–] 3 points 3 weeks ago (1 child)

    However, the study found compared to the placebo group:

    • Participants treated with semaglutide exhibited a broad pattern of slower biological aging across epigenetic clocks linked to inflammation and blood, brain, heart, kidney, liver and metabolic health.

    • The drug slowed the pace of biological aging by 9 %, as measured by the DunedinPACE epigenetic clock.

    • The drug significantly slowed biological processes associated with the risk of all‑cause mortality and age-related disease, as measured by the PCGrimAgeepigenetic clock.

    It's just that the study focused on people with a particular condition so it takes more studies to know if it affects the general population similarly.

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  • [–] 3 points 3 weeks ago

    are these unique to the glp-1 intervention or are they echos of ketone production, fat metabolism, increased insulin sensitivity... are there more effective ways to achieve the same marker improvements without using a glp-1? (obviously yes)

    Making casual claims like slow biological aging requires the context which the data is based, and a demonstration of the mechanisms.

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    • [–] 4 points 3 weeks ago

    Dayum, but I’m already scrawny ☹️

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    [–] 2 points 3 weeks ago

    I feel like it makes people look gaunt. Also risk for literally "loss of optic nerve".

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