I tried to imbue it with a Wand of Disintegration and the game immediately crashed. I was still in the mirror room at the time.

I'm playing Battlemage, and have the talent that returns the previous staff wand once per player level, not that the staff currently appeared to have an imbued wand, not even Magic Missile.

Update:

This time I quit my game before trying again so it would save. The crash happened again, so it's repeatable. I was not in the mirror room this time, and trying to imbue other wands crashes, too.