They've always been edgy contrarians. And with the national media so fully, apologetically, slavishly in the bag for this administration, all you can do as a contrarian is take shots at the President.
I think the other side of the episode - Cartman losing his shit because he's not the biggest online racist anymore - says it all. These guys want to be the ones producing the cringe transphobic episodes and climate change denialism and weirdly sexualized takes on undocumented immigration.
To quote Matt Stone
"I hate conservatives but I really fucking hate liberals."
They don't want this. They want to be mocking people who drive electric cars and use bidets. Thank goodness tiny dick jokes and "that bitch is fugly" jokes are still on the table or they wouldn't have a show left.